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"Antibiotic Resistance in Louisiana"

fdabramo

I situate my research at the crossroads of history, philosophy, sociology and anthropology of science. In the past, I have focused on epigenetics, environmental research, empirical bioethics and environmental justice, within and outside the academia, as you can read here, or here. Now I am focusing on antibiotic resistance, and I use it as a lens to interpret the contradictions of the last century derived by industrial production, environmental degradation and biomedical cultures.

What interests me is the (at that time) new epistemic discourse that since the Forties has been produced to explain morphological changes of organisms produce when they experience new environmental conditions or perturbations. Through an important experiment at the base of the so-called concept of genetic assimilation, Conrad H. Waddington showed that a thermic shock can produce changes in wings’ veins of fruit flies, changes that can eventually be inherited across generations, without the environmental trigger that caused them.

This focus on production and (genetic) storage of biological differences elicited by the environment is nowadays coupled with the knowledge produced through microbiome research that explains the phenotypic patterns that recur across generations.

In a thought-provoking twist, with microbiome research, the focus shifts from production and inheritance of biological differences to production and inheritance of biological similarities. Microbiome research shows that some phenotypic patterns are allowed by ecological communities of microorganisms composing all animals. Bacteria allow the development and functioning of our bodies within an epistemic framework that is now key to understand biology. The network of vessels composing mammals’ stomach is formed through cellular differentiation and expression of genes coordinated by bacteria. The same is true for our immune system that is coordinated by gut bacteria. Food, which is an important aspect of our lives also impacts on this microecology and mediates between our biological functions and functioning of means of production whose parts dedicated to food production have immense importance for our biology and our internal and external ecologies. Antibiotic resistance is one of the crossroads where culture, biology, history and the Anthropocene meet. Indeed, Antibiotic resistance shows that means of production of our societies have an even more widespread, deep and allegedly unexpected impact on the biology of animals and plants. The microorganism can indeed adapt to resist the selective toxicity of antibiotics. Moreover, bacteria can transfer their genetic code horizontally, by touch, so that we can acquire antibiotic resistance by eating food that functions as a vector, by hosting lice on our heads and many other contacts. Bacteria that are resistant to antibiotics that have been used as growth factors in animal husbandry and to prevent diseases in livestock and aquaculture, spread in natural ecosystems and can be found in wild species. Rivers and estuarine waters are places hosting antibiotic resistance.

Searching on PubMed (the search engine for biomedical literature) titles of articles containing the terms ‘antimicrobial’ and ‘Louisiana’ I retrieved just one twelve-years-old article. No results with terms such as 'Mississippi' or 'New Orleans'. The authors collected and analysed Oysters from both waters of Louisiana Gulf and in restaurants and food retailers in Baton Rouge. In most of the samples gathered, scientists recognised the presence of bacteria (Vibrio parahaemolyticus and Vibrio vulnificus) resistant to specific antimicrobials. Food production is indeed the first factor in terms of the quantity of antibiotics used. This use and related antibiotic resistance impact all the living beings present in a specific area, and can easily travel around the globe through many channels. As Littman & Viens have highlighted, a sustainable future is a future without antibiotics as “there may be no truly sustainable way of using antibiotics in the long-run, as microorganisms have shown to be almost infinitely adaptable since the first introduction of antibiotics” (Littman & Viens 2015). But in the meanwhile, we need to use them and antibiotic resistance is a phenomenon that can be better studied through environmental research, by analysing wild species and emissions nearby livestock, for instance.

The study that I retrieved focuses on Oysters. But what about antibiotic resistance conveyed through food that is consumed by the most?

What about exposures of communities that are living in highly polluted areas?

And what is the additive value on antibiotic resistance for individuals who experience the presence of industrial pollutants and that live in areas where cancer epidemics are registered?

In this respect, there is a strategy to cope with the issue of antibiotic resistance promoted by the Center for Disease Control and Prevention. The document doesn’t mention any action to monitor and regulate the production and usage of antibiotics in livestock. Nevertheless, the CDC wants to scrutinise, through genome sequencing, “Listeria, Salmonella, Campylobacter, and E. coli and uploads sequence data into PulseNet for nationwide monitoring of outbreaks and trends.” Moreover, the document reports that “In Fiscal Year 2019, Louisiana will begin simultaneously monitoring these isolates for resistance genes. When outbreaks are detected, local CDC-supported epidemiologists investigate the cases to stop spread.”

The questions that I would like to ask (to local ppl, activists, researchers, practitioners..) are:

What could be the epidemiologic characteristics (socioeconomic status, gender, residence..) of the populations more vulnerable to antibiotic resistance?

What is the additive role of antibiotic resistance for people living in highly polluted areas?

What is the impact of antibiotic resistance for people and patients living in areas where cancer incidence is high?

 

And on the long run I am interested in imagining possible strategies to not only living with the problem but also to tackle the problem itself, which means to develop strategies to answer the questions:

Why antibiotic resistance, which is known since a century, it’s a problem on the rise?

What is the role and interest of capitalism, in terms of profit-making of corporations, knowledge production and environmental degradation, in not being able to resolve antibiotic resistance?

What can be strategies of local communities to tackle the problem and to promote environmental justice in terms of alliances with ecologists, doctors, epidemiologists and other activists?

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Sara_Nesheiwat

I read up on what constitutes people who can classify as peri-disaster personnel, I found the concept interesting and didn't realize there was a specific name to classify those people, I always wondered about the people who were indirectly effected by a disaster or partially effected due to proximity. I also researched comorbidity and common forms of mental illness that arise in post disaster survivors. 

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Zackery.White

Sonja D. Schmid is a professor at Virginia Tech in Northern Virginia. Her studies and research focus on “technology policy, qualitative studies of risk, energy policy, and nuclear nonproliferation” as stated on her directory website for VT. She has been an associate professor since 2011 and her current project, such as the article suggests, is investigating the challenges of globalizing nuclear emergency response. She has many published articles including her most recent publication in Global Forum earlier this year titled “What if there’s a next time? Preparedness after Chernobyl and Fukushima - A European-American response.”

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Sara_Nesheiwat

This article has been cited and referred to in an study published in the Journal of Radiological Protection. It is entitled 'Chernobyl and Fukushima-where are we now?' Written by Richard Wakeford. 

http://iopscience.iop.org/article/10.1088/0952-4746/36/2/E1

This paper is also referenced by 9 other papers and is published in numerous oncology related journals.

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Zackery.White

Doctors without Borders (MSF) is an organization that provides emergnecy medical aid to communities affeted by conflict, epidemics, disasters, and more. It's composed of mostly physicians and other health care workers, but is accepting of individuals which will help it achieve it's goals. MSF takes a neutral stance on issues as they only strictly abide by medical ethics.

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Sara_Nesheiwat

The Chernobyl nuclear power plant explosion in 1986 led to a ten day reactor fire that resulted in a large and unknown amount of radiation spilling into the surrounding areas in Ukraine. This caused the contamination of the environments and those around the reactor. Hundreds of thousands of people had to evacuate and to this day it remains to be an issue. Due to this controversy that still surrounds this disaster, the IAEA, FAO, UNDP, UNEP, OCHA, UNSCEAR and WHO created the Chernobyl Forum. They generate "authoritative consensual statements" on the environmental consequences due to the radiation exposure. Ultimately they and this event in Chernobyl are what called for this report. 

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Sara_Nesheiwat
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American Red Cross doesn't claim to have or offer new or unique techniques to attending to disaster. Yet in my opinion, The American Red Cross is one of the greatest organizations in terms of disaster response and it is truly made up of people who want to help others. We are lucky to have such a large scale magnitude of volunteers gathered through one organization to answer to both small needs in their community, be it a blood drive or house fire, to large disaster relief efforts after Katrina or 9/11. The American Red Cross has single handedly offered aid to so many families in America and saved more lives than any other single independent organization run by a majority of volunteers. The American Red Cross offers a wide range of coverage in terms of disaster types they respond to and frequency, so in my opinion, they are a very, very unique organization and offer something that I have not seen any other organization offer the way they do.