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The Cold War was a principal motivating factor for the IPPNW who aims to abolish nuclear weapons and thereby prevent nuclear war and destruction.

As an activist organization, the IPPNW organizes awareness campaigns, conducts and funds research efforts, sponsors conferences, applies political pressure, and develops educational courses and training programs.

The IPPNW is a non-partisan federation of various national medical groups from over 63 countries. The organization represents physicians, medical students, healthcare professionals, and other concerned stakeholders.

The goal of this organization is to secure a more peaceful and safe world free from the threat of nuclear war and destruction.