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The mission statement summarizes the aim of the Partners in Health as "to bring the benefits of modern medical science to those most in need of them and to serve as an antidote to despair". They are available to many of the suffering third-world countries that lack modern medicine. They are aided by the most prominent health care leaders in the world. They want to treat those in need of medical care like family, not just giving, but making them feel like they belong and are deserving of the same level of care.

Anyone can join, according to the website form. They are partnered with many large foundations and relief funds.

The organization saw cholera cases pop up and immediately opened clinics in those areas to try to reduce the impact and spread of cholera, as well as mental health services for families that lost loved ones. They vaccinated for cholera, and improved the infrastructure in the areas to reduce the spread of all waterborne diseases.