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"Antibiotic Resistance in Louisiana"

fdabramo

I situate my research at the crossroads of history, philosophy, sociology and anthropology of science. In the past, I have focused on epigenetics, environmental research, empirical bioethics and environmental justice, within and outside the academia, as you can read here, or here. Now I am focusing on antibiotic resistance, and I use it as a lens to interpret the contradictions of the last century derived by industrial production, environmental degradation and biomedical cultures.

What interests me is the (at that time) new epistemic discourse that since the Forties has been produced to explain morphological changes of organisms produce when they experience new environmental conditions or perturbations. Through an important experiment at the base of the so-called concept of genetic assimilation, Conrad H. Waddington showed that a thermic shock can produce changes in wings’ veins of fruit flies, changes that can eventually be inherited across generations, without the environmental trigger that caused them.

This focus on production and (genetic) storage of biological differences elicited by the environment is nowadays coupled with the knowledge produced through microbiome research that explains the phenotypic patterns that recur across generations.

In a thought-provoking twist, with microbiome research, the focus shifts from production and inheritance of biological differences to production and inheritance of biological similarities. Microbiome research shows that some phenotypic patterns are allowed by ecological communities of microorganisms composing all animals. Bacteria allow the development and functioning of our bodies within an epistemic framework that is now key to understand biology. The network of vessels composing mammals’ stomach is formed through cellular differentiation and expression of genes coordinated by bacteria. The same is true for our immune system that is coordinated by gut bacteria. Food, which is an important aspect of our lives also impacts on this microecology and mediates between our biological functions and functioning of means of production whose parts dedicated to food production have immense importance for our biology and our internal and external ecologies. Antibiotic resistance is one of the crossroads where culture, biology, history and the Anthropocene meet. Indeed, Antibiotic resistance shows that means of production of our societies have an even more widespread, deep and allegedly unexpected impact on the biology of animals and plants. The microorganism can indeed adapt to resist the selective toxicity of antibiotics. Moreover, bacteria can transfer their genetic code horizontally, by touch, so that we can acquire antibiotic resistance by eating food that functions as a vector, by hosting lice on our heads and many other contacts. Bacteria that are resistant to antibiotics that have been used as growth factors in animal husbandry and to prevent diseases in livestock and aquaculture, spread in natural ecosystems and can be found in wild species. Rivers and estuarine waters are places hosting antibiotic resistance.

Searching on PubMed (the search engine for biomedical literature) titles of articles containing the terms ‘antimicrobial’ and ‘Louisiana’ I retrieved just one twelve-years-old article. No results with terms such as 'Mississippi' or 'New Orleans'. The authors collected and analysed Oysters from both waters of Louisiana Gulf and in restaurants and food retailers in Baton Rouge. In most of the samples gathered, scientists recognised the presence of bacteria (Vibrio parahaemolyticus and Vibrio vulnificus) resistant to specific antimicrobials. Food production is indeed the first factor in terms of the quantity of antibiotics used. This use and related antibiotic resistance impact all the living beings present in a specific area, and can easily travel around the globe through many channels. As Littman & Viens have highlighted, a sustainable future is a future without antibiotics as “there may be no truly sustainable way of using antibiotics in the long-run, as microorganisms have shown to be almost infinitely adaptable since the first introduction of antibiotics” (Littman & Viens 2015). But in the meanwhile, we need to use them and antibiotic resistance is a phenomenon that can be better studied through environmental research, by analysing wild species and emissions nearby livestock, for instance.

The study that I retrieved focuses on Oysters. But what about antibiotic resistance conveyed through food that is consumed by the most?

What about exposures of communities that are living in highly polluted areas?

And what is the additive value on antibiotic resistance for individuals who experience the presence of industrial pollutants and that live in areas where cancer epidemics are registered?

In this respect, there is a strategy to cope with the issue of antibiotic resistance promoted by the Center for Disease Control and Prevention. The document doesn’t mention any action to monitor and regulate the production and usage of antibiotics in livestock. Nevertheless, the CDC wants to scrutinise, through genome sequencing, “Listeria, Salmonella, Campylobacter, and E. coli and uploads sequence data into PulseNet for nationwide monitoring of outbreaks and trends.” Moreover, the document reports that “In Fiscal Year 2019, Louisiana will begin simultaneously monitoring these isolates for resistance genes. When outbreaks are detected, local CDC-supported epidemiologists investigate the cases to stop spread.”

The questions that I would like to ask (to local ppl, activists, researchers, practitioners..) are:

What could be the epidemiologic characteristics (socioeconomic status, gender, residence..) of the populations more vulnerable to antibiotic resistance?

What is the additive role of antibiotic resistance for people living in highly polluted areas?

What is the impact of antibiotic resistance for people and patients living in areas where cancer incidence is high?

 

And on the long run I am interested in imagining possible strategies to not only living with the problem but also to tackle the problem itself, which means to develop strategies to answer the questions:

Why antibiotic resistance, which is known since a century, it’s a problem on the rise?

What is the role and interest of capitalism, in terms of profit-making of corporations, knowledge production and environmental degradation, in not being able to resolve antibiotic resistance?

What can be strategies of local communities to tackle the problem and to promote environmental justice in terms of alliances with ecologists, doctors, epidemiologists and other activists?

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michael.lee

2002 RAND Corporation Report, The Global Threat of New and Reemerging Infectious Disease

2007 World Health Report, A Safer Future: Global Public Health Security in the 21st Century

"Pandemic and All-Hazards Preparedness Act (PAHPA)," Public Law No. 109-417

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seanw146

The film takes more of an observer stance than an active role. The corrective action I imagine being effective is better preparedness on the local national and international level to be able to better respond not only to the direct impact of the disease but also the secondary social impacts to the community such as food, water, enforcing emergency orders, and travel restrictions. 

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seanw146

1) I followed up on the old safety features of the World Trade Center. Sprinklers were the only feature that stood out from a fire safety video by the New York and New Jersey Port Authority for the World Trade Center (made 1996). https://www.youtube.com/watch?v=aBM9-y8gfHo. However the fire was much too large for them to put out, and may have even made it worse because water, when in contact with molten aluminum explodes.

 

2) Next I looked into why and how the World Trade Center (WTC) collapse happened. The WTC did not have concrete core or outer. Most high-rise buildings have one or the other as concrete is not subject to fire. The WTC steel trusses and columns were fireproofed with spray foam which fell off the building on impact with the airplane. The crash through the building resulted in flammable debris getting pushed to the far walls and corners, the most vulnerable location, and fatally weakening the WTC’s steel core. NIST report never stated that the fire melted the steel beams, steel melts at 2750 degrees F, but looses half its strength at 1100 F. Parts of the WTC fires reached 1800 F on that day. With the weakening, the trusses began to sag, bowing inward causing all of the weight to rest on the perimeter columns which could not bear the load and eventually snapped. After the first floor fell, the “pan-caking” effect resulted in each floor collapsing the one beneath it.

 

3) Lastly I looked at the new disaster prevention features of One World Trade Center. The key features which the Twin Towers were lacking are: a concrete core with stairwells located in center, larger than required staircases, and a separate first responder stairwell. Many experts believe if the WTC had a concrete core, they would not have fallen. 

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michael.lee
Annotation of
  • "It’s the abuse and violence at Rikers that have received the most attention. But there’s another dimension to the ongoing disaster there: the dangerous environmental conditions. Rikers is built on a landfill. The ground underneath the facilities is unstable and the decomposing garbage emits poisonous methane gas. In addition to extreme heat and poor air quality, flooding and crumbling infrastructure pose a serious threat, especially when superstorms like Hurricane Sandy strike. As the violence and human rights violations worsen, so do the environmental circumstances surrounding Rikers."
  • "It’s true that the damage to Rikers wasn’t extensive. However, Sandy’s impact brings up a major question: How will the island fare in future natural disasters? When bigger, stronger hurricanes and snowstorms strike? A year earlier, during Hurricane Irene, The New York Times revealed that the Department of Correction did not have a full evacuation plan for Rikers Island—or even a plan to evacuate the population in buildings prone to flooding."
  • "'We’re pouring money into an archaic structure, when we should be asking how we can reduce the population in order to close it,' says Johnny Perez of Urban Justice Center. 'The problem with Rikers Island is Rikers Island. … [The conditions] really border on cruel and unusual punishment.' In the meantime, the next heatwave, hurricane, or big snowstorm could spell disaster."

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michael.lee

A professor of anthropology at the University of California, Berkeley, Dr. Adriana Petryna holds a doctorate degree in Anthropology from UC Berkeley and a masters degree in Anthropology as well as a bachelor of science degree in Architecture from the University of Michigan. She has conducted her research on medical anthropology and social sciences, as well as on nuclear science.

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seanw146

1) I looked into how other countries that faced significant disaster dealt with their displaced populations. (http://fukushimaontheglobe.com/the-earthquake-and-the-nuclear-accident/situation-of-the-evacuees)

2) Next, I researched the American Psychological Association’s views on mental health and disasters. (http://www.apa.org/topics/disasters/)

3) Lastly, I looked into “price gouging” during and after natural disasters and both sides of the argument. Pros: (http://www.huffingtonpost.ca/peter-mccaffrey/5-reasons-price-gouging-is-okay_b_3487621.html) and cons: (https://www.uvm.edu/~vlrs/doc/pricegou.html)