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"Antibiotic Resistance in Louisiana"

fdabramo

I situate my research at the crossroads of history, philosophy, sociology and anthropology of science. In the past, I have focused on epigenetics, environmental research, empirical bioethics and environmental justice, within and outside the academia, as you can read here, or here. Now I am focusing on antibiotic resistance, and I use it as a lens to interpret the contradictions of the last century derived by industrial production, environmental degradation and biomedical cultures.

What interests me is the (at that time) new epistemic discourse that since the Forties has been produced to explain morphological changes of organisms produce when they experience new environmental conditions or perturbations. Through an important experiment at the base of the so-called concept of genetic assimilation, Conrad H. Waddington showed that a thermic shock can produce changes in wings’ veins of fruit flies, changes that can eventually be inherited across generations, without the environmental trigger that caused them.

This focus on production and (genetic) storage of biological differences elicited by the environment is nowadays coupled with the knowledge produced through microbiome research that explains the phenotypic patterns that recur across generations.

In a thought-provoking twist, with microbiome research, the focus shifts from production and inheritance of biological differences to production and inheritance of biological similarities. Microbiome research shows that some phenotypic patterns are allowed by ecological communities of microorganisms composing all animals. Bacteria allow the development and functioning of our bodies within an epistemic framework that is now key to understand biology. The network of vessels composing mammals’ stomach is formed through cellular differentiation and expression of genes coordinated by bacteria. The same is true for our immune system that is coordinated by gut bacteria. Food, which is an important aspect of our lives also impacts on this microecology and mediates between our biological functions and functioning of means of production whose parts dedicated to food production have immense importance for our biology and our internal and external ecologies. Antibiotic resistance is one of the crossroads where culture, biology, history and the Anthropocene meet. Indeed, Antibiotic resistance shows that means of production of our societies have an even more widespread, deep and allegedly unexpected impact on the biology of animals and plants. The microorganism can indeed adapt to resist the selective toxicity of antibiotics. Moreover, bacteria can transfer their genetic code horizontally, by touch, so that we can acquire antibiotic resistance by eating food that functions as a vector, by hosting lice on our heads and many other contacts. Bacteria that are resistant to antibiotics that have been used as growth factors in animal husbandry and to prevent diseases in livestock and aquaculture, spread in natural ecosystems and can be found in wild species. Rivers and estuarine waters are places hosting antibiotic resistance.

Searching on PubMed (the search engine for biomedical literature) titles of articles containing the terms ‘antimicrobial’ and ‘Louisiana’ I retrieved just one twelve-years-old article. No results with terms such as 'Mississippi' or 'New Orleans'. The authors collected and analysed Oysters from both waters of Louisiana Gulf and in restaurants and food retailers in Baton Rouge. In most of the samples gathered, scientists recognised the presence of bacteria (Vibrio parahaemolyticus and Vibrio vulnificus) resistant to specific antimicrobials. Food production is indeed the first factor in terms of the quantity of antibiotics used. This use and related antibiotic resistance impact all the living beings present in a specific area, and can easily travel around the globe through many channels. As Littman & Viens have highlighted, a sustainable future is a future without antibiotics as “there may be no truly sustainable way of using antibiotics in the long-run, as microorganisms have shown to be almost infinitely adaptable since the first introduction of antibiotics” (Littman & Viens 2015). But in the meanwhile, we need to use them and antibiotic resistance is a phenomenon that can be better studied through environmental research, by analysing wild species and emissions nearby livestock, for instance.

The study that I retrieved focuses on Oysters. But what about antibiotic resistance conveyed through food that is consumed by the most?

What about exposures of communities that are living in highly polluted areas?

And what is the additive value on antibiotic resistance for individuals who experience the presence of industrial pollutants and that live in areas where cancer epidemics are registered?

In this respect, there is a strategy to cope with the issue of antibiotic resistance promoted by the Center for Disease Control and Prevention. The document doesn’t mention any action to monitor and regulate the production and usage of antibiotics in livestock. Nevertheless, the CDC wants to scrutinise, through genome sequencing, “Listeria, Salmonella, Campylobacter, and E. coli and uploads sequence data into PulseNet for nationwide monitoring of outbreaks and trends.” Moreover, the document reports that “In Fiscal Year 2019, Louisiana will begin simultaneously monitoring these isolates for resistance genes. When outbreaks are detected, local CDC-supported epidemiologists investigate the cases to stop spread.”

The questions that I would like to ask (to local ppl, activists, researchers, practitioners..) are:

What could be the epidemiologic characteristics (socioeconomic status, gender, residence..) of the populations more vulnerable to antibiotic resistance?

What is the additive role of antibiotic resistance for people living in highly polluted areas?

What is the impact of antibiotic resistance for people and patients living in areas where cancer incidence is high?

 

And on the long run I am interested in imagining possible strategies to not only living with the problem but also to tackle the problem itself, which means to develop strategies to answer the questions:

Why antibiotic resistance, which is known since a century, it’s a problem on the rise?

What is the role and interest of capitalism, in terms of profit-making of corporations, knowledge production and environmental degradation, in not being able to resolve antibiotic resistance?

What can be strategies of local communities to tackle the problem and to promote environmental justice in terms of alliances with ecologists, doctors, epidemiologists and other activists?

Migration and Movement

AKPdL

Might movement, both forced and voluntary, be a defining characteristic of the anthropocene? If not, where might this quality find a home within the analytic questions? 

In preparation for the field school I am reading Edward Baptist's The Half Has Never Been Told. Chapter 1, 'Feet', tells the history of the forced migration of slaves from northern coastal plantation colonies to the south. Men and Women, chained together by iron were forced to walk in coffles to South Carolina or Georgia. As Baptist writes 

Men of the chain couldn’t act as individuals; nor could they act as a collective, except by moving forward in one direction. Even this took some learning. Stumble, and one dragged someone else lurching down by the padlock dangling from his throat. Many bruised legs and bruised tempers later, they would become one long file moving at the same speed, the same rhythm, no longer swinging linked hands in the wrong direction (25).

One of the arguments presented in this book is that American capitalism, as we know it today, would be impossible without the the foundations put in place by slave labor. The early chapters also make clear that forced migration, the movement and redistribution of enslaved persons, allowed for the southern states to expand agricultural production and increase white wealth. This eventual transformation of land and capital was predicated on the movement of peoples from one place to another, and as the passage above suggests, this movement had a rhythm, a timbre, a musical modality. 

I contrast this with Zenia Kish's article "My FEMA People": Hip-hop as disaster recovery in Katrina Diaspora where she argues that the music that emerged following Katrina was the first time American hip-hop engaged with "the thematic of contemporary black migration as a mass phenomenon in any significant way" (674). This article also draws attention to the rhythms of post Katrina life; the call and response of Bounce, the vibrations of trauma. Although lyrical expression proved the most potent way for artists to narrate the impact of environmental change and political neglect, the music itself was borne out of the experience of moving through and with disaster. 

Both writings point to the importance of further exploring the rhythms of mobilities as they relate to environmental transformations. I'm struggling to see where this point of inquiry maps to the analytic questions and may be worth some further exploration. 

Baptist, Edward. The Half Has Never Been Told: Slavery and the Making of American Capitalism. Basic Books. New York. (2014)

Kish, Zenia. “"My FEMA People ": Hip-Hop as Disaster Recovery in the Katrina Diaspora.” American Quarterly. 61, no. 3 (2009): 671–92.

Urban Water

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I am currently at the Ecological Society of America annual conference, so I am a bit limited on time to dig into New Orleans. I want to share the link below to the NoLA Urban Water plan. Even the nomenclature of 'urban water' allows us to think a bit deeper about how natural resources take on new characteristics, transformations, and meanings based on the spaces they inhabit. For instance, what does it mean for water to be Urban and how might that designation change how it is governed or interpreted?  

Furthermore, in thinking through the Field School's call to investigate Slavery and Labor, what might be the work of creating specifically urban waters? What forms of scientific knowledge and technological devices make urban water legible?

In asking these questions I'm thinking through a recent presentation I saw by Billy Hall who called attention to the wedding of environment and race in Baltimore City as a mechanism to encourage policies of segregation. I'm inclined, as we move into New Orleans, to think further on this provocation to examine how powerful social perceptions are wedded to techniques of governance to achieve publicly oriented outcomes. 

https://livingwithwater.com/blog/urban_water_plan/about/

Baltimore City - Inner Harbor Watershed

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Zoning – Percent of Watershed Area
Commercial – 12.7%
Educational - 0.0%
Hospital – 1.3%
Industrial – 45.8%
Office – 1.3%
Open Space – 7.4%
Residential Detached 1.6%
Residential High Density Row House - 20.1%
Residential Mixed Use -1.7%
Residential Multifamily – 0.2%
Residential Low Density Row House – 3.7%
Residential Traditional – 1.1%
No Data – 3%

Land Use Type - % Watershed Area 

Barren Land - 2.4% 
Commercial -7.0% 
Forest - 1.9% 
High Density Residential - 25.9% 
Medium Density Residential - 1.4% 
Low Density Residential - 0% 
Industrial - 42.0% 
Institutional - 7.4% 
Other Developed Land -7.8% 
Transportation - 3.0% 
Wetland - 0% 
Water -1.3% 

Property Ownership – Percent of Watershed Area

City Owned – 12.8%
Private – 37.3%
Right of Way – 23.1%
Rail Roads – 25.4%
State Owned – 2.2%
Federal Owned – 0.5%

Autoethnography of Industry

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The environmental legacies left behind by industrial production are pervasive in the air, the soil, and the water. This elemental elixer surrounds us.

In the field of STS, it is perhaps obvious to suggest that institutions have cultures, norms, standards, and professional ways of being. Yet, what are we to make of the results of industry telling its own past publically. The corporate origin story could be a footnote in Joseph's Campbells work. The allure of the lone individual working tirelessly until an innovation is produced and the market takes over. 

Yet, the Wood River Refinery tells a different story. One about place, about people, about the terrible minutia of life lived within bureaucracy. Yes, the story told is glossy and teleological, but the question emerges. What can be learned about the stories industry tells about itself? What do these artifacts contribute to histories and what weight do we give to these stories within the Anthropocene?

The factory at Wood River is both a place where labor is maximized for profit, but also where worker devote 40 precious hours of their week. Lives persist and even thrive in the factory. Are the stories of these lives at Wood River? 

Who manages the environment?

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Annotation of

Pb. Atomic Number 82. 

Divorced from its placement on the periodic table, the element finds itself exposed in a garden, nestled between bioretention and a bus depot. 

Researchers came into to town and made the lead in the soil ledgible and knowable. Soil was tested and this dirt pile was labeled a hot spot. The soil, through analysis in a lab, became suddently differentiatiated from it's environment.  Speculation on the origins of now changed earth ran rampant. Yes, the lead is a chemical legacy, but from where or from whom? Perhaps a long shuttered paint store was dumping its expired wares behind a shop. The chemical legacy proves persistant, but its origin story has degrated with time. Would there be any purpose to tracking the origin of the spot? Are there even actors to hold accountable? Should resources be spent to remediate the small environmental harms when others lurk that are larger in scale in and in affect?

While we ponder, the site is marked by a material more durable than our more human legacies. A concrete marker, or bench (depending on your tolerance for risk), tells a visitor of a history bound the earth. To intervene, the site is covered with dirt, a sign cautions the curious to resist the urge to disturb. To remediate this spot would take time, money, and expertise when all those resources are in short supply. Instead, the area is stewarded to make visible its contents. A delightfully perverse cue to care, inviting disuse and intentional avoidance. Let the earth lie.

Future Participation

AKPdL

I would love to be involved going forward in this project. I plan on attending 4S and could concieveably participate in a presentation on the work in St. Louis. I also can provide administrative support to make that field campus happen. 

Additionally, my colleagues in Baltimore are enthusiastic about bringing a Field Campus to the city. I have a project retreat early next week where I will be presenting on my participation in the campus and some brief ideas for how my research project and the Baltimore Ecosystem Study might be able to be involved. 

General Feedback

AKPdL
  • I was most interested in the time spent at GCADD. I loved learning about that space, it's history, and the participants working to build it up. 
  • I came out of the field campus extremely exhaused. Personally I love this feeling. There is something extremely comforting to me about having a brain exploding with new ideas and a body too tired to do anything with it. I do have concerns about how experiences like the field campus, and the exhaustive toll they take, may limit the audience who chooses to participate. I wonder if future field campuses might think a little more about how make the experience more accessible to participants with different physical or mental health needs. 
  • While I enjoyed the breadth of perspectives that participated in this experience, I think the campus could benefit with the inclusion of more scientists. At Weldon Spring, I really wish we had an engineer in our group to talk about building a site like that. Even if it might be difficult to get subject area experts, just a few ecologists or engineers in the room could have added depth to our conversations. 

Green Stormwater Infrastucture

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Contextual Articles
Landscapes with Purpose
One STL
Metropolitan St. Louis Sewer District
EPA - Green Infrastructure
Green City Coalition

Green Stormwater Infrastructure
Prior to the 1970's, many US cities managed stormwater through piped conveyance systems. Flooding was once considered the most significant risk associated with rainfall. System builders built water infrastructure to accommodate volume. Most cities in the US have what is called a combined sewer system (CSS). This system pipes stormwater and municipal wastewater together. The water is then treated and then released into receiving bodies. St. Louis is one of the rare cities (Baltimore, where my research is based is another) that has a municipal separated stormwater system (MS4). In a separated system, a system of pipes keeps stormwater separate from other wastewaters. 

In the 1970's ecological research, some of which came from the EPA's National Urban Research Program, began to demonstrate that nutrients in runoff were responsible for environmental pollution. In turn, municipal engineers transitioned to thinking about tools and techniques for decreasing this nutrient load. In St. Louis, the separated system operates under a federal consent decree with the EPA where the city must reduce the overall percentage of nutrients (nitrogen and phosphorus) carried through runoff. The most recent strategy for managing this problem is Green Stormwater Infrastructure (GSI). Although the problems associated with GSI are of local relevance, they are managed through state and federal governance strategies.

While GSI is difficult to define, many times installations feature landscaped elements that aim to mimic the pre-development hydrological processes of a given site. In urban areas, these projects often utilize vacant lands or reduce existing impervious surface cover. Many planners and community groups also suggest that GSI provides additional social benefits through an increase in community green space, reduction in urban heat island, and improved property values. 

This image from Missouri Coalition for the environment brings together the many suggested benefits of implementing these technologies. The diagram also provokes some questions that may interest us in our project; Does GSI represent a paradigmatic shift in techniques of stormwater management? Does natural or environmental mimicry in engineering projects act as a corrective to the anthropocene, or are these technologies merely a response? How are the social, economic, and technical benefits of GSI calculated and have attendent burdens been considered as well?