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"Antibiotic Resistance in Louisiana"

fdabramo

I situate my research at the crossroads of history, philosophy, sociology and anthropology of science. In the past, I have focused on epigenetics, environmental research, empirical bioethics and environmental justice, within and outside the academia, as you can read here, or here. Now I am focusing on antibiotic resistance, and I use it as a lens to interpret the contradictions of the last century derived by industrial production, environmental degradation and biomedical cultures.

What interests me is the (at that time) new epistemic discourse that since the Forties has been produced to explain morphological changes of organisms produce when they experience new environmental conditions or perturbations. Through an important experiment at the base of the so-called concept of genetic assimilation, Conrad H. Waddington showed that a thermic shock can produce changes in wings’ veins of fruit flies, changes that can eventually be inherited across generations, without the environmental trigger that caused them.

This focus on production and (genetic) storage of biological differences elicited by the environment is nowadays coupled with the knowledge produced through microbiome research that explains the phenotypic patterns that recur across generations.

In a thought-provoking twist, with microbiome research, the focus shifts from production and inheritance of biological differences to production and inheritance of biological similarities. Microbiome research shows that some phenotypic patterns are allowed by ecological communities of microorganisms composing all animals. Bacteria allow the development and functioning of our bodies within an epistemic framework that is now key to understand biology. The network of vessels composing mammals’ stomach is formed through cellular differentiation and expression of genes coordinated by bacteria. The same is true for our immune system that is coordinated by gut bacteria. Food, which is an important aspect of our lives also impacts on this microecology and mediates between our biological functions and functioning of means of production whose parts dedicated to food production have immense importance for our biology and our internal and external ecologies. Antibiotic resistance is one of the crossroads where culture, biology, history and the Anthropocene meet. Indeed, Antibiotic resistance shows that means of production of our societies have an even more widespread, deep and allegedly unexpected impact on the biology of animals and plants. The microorganism can indeed adapt to resist the selective toxicity of antibiotics. Moreover, bacteria can transfer their genetic code horizontally, by touch, so that we can acquire antibiotic resistance by eating food that functions as a vector, by hosting lice on our heads and many other contacts. Bacteria that are resistant to antibiotics that have been used as growth factors in animal husbandry and to prevent diseases in livestock and aquaculture, spread in natural ecosystems and can be found in wild species. Rivers and estuarine waters are places hosting antibiotic resistance.

Searching on PubMed (the search engine for biomedical literature) titles of articles containing the terms ‘antimicrobial’ and ‘Louisiana’ I retrieved just one twelve-years-old article. No results with terms such as 'Mississippi' or 'New Orleans'. The authors collected and analysed Oysters from both waters of Louisiana Gulf and in restaurants and food retailers in Baton Rouge. In most of the samples gathered, scientists recognised the presence of bacteria (Vibrio parahaemolyticus and Vibrio vulnificus) resistant to specific antimicrobials. Food production is indeed the first factor in terms of the quantity of antibiotics used. This use and related antibiotic resistance impact all the living beings present in a specific area, and can easily travel around the globe through many channels. As Littman & Viens have highlighted, a sustainable future is a future without antibiotics as “there may be no truly sustainable way of using antibiotics in the long-run, as microorganisms have shown to be almost infinitely adaptable since the first introduction of antibiotics” (Littman & Viens 2015). But in the meanwhile, we need to use them and antibiotic resistance is a phenomenon that can be better studied through environmental research, by analysing wild species and emissions nearby livestock, for instance.

The study that I retrieved focuses on Oysters. But what about antibiotic resistance conveyed through food that is consumed by the most?

What about exposures of communities that are living in highly polluted areas?

And what is the additive value on antibiotic resistance for individuals who experience the presence of industrial pollutants and that live in areas where cancer epidemics are registered?

In this respect, there is a strategy to cope with the issue of antibiotic resistance promoted by the Center for Disease Control and Prevention. The document doesn’t mention any action to monitor and regulate the production and usage of antibiotics in livestock. Nevertheless, the CDC wants to scrutinise, through genome sequencing, “Listeria, Salmonella, Campylobacter, and E. coli and uploads sequence data into PulseNet for nationwide monitoring of outbreaks and trends.” Moreover, the document reports that “In Fiscal Year 2019, Louisiana will begin simultaneously monitoring these isolates for resistance genes. When outbreaks are detected, local CDC-supported epidemiologists investigate the cases to stop spread.”

The questions that I would like to ask (to local ppl, activists, researchers, practitioners..) are:

What could be the epidemiologic characteristics (socioeconomic status, gender, residence..) of the populations more vulnerable to antibiotic resistance?

What is the additive role of antibiotic resistance for people living in highly polluted areas?

What is the impact of antibiotic resistance for people and patients living in areas where cancer incidence is high?

 

And on the long run I am interested in imagining possible strategies to not only living with the problem but also to tackle the problem itself, which means to develop strategies to answer the questions:

Why antibiotic resistance, which is known since a century, it’s a problem on the rise?

What is the role and interest of capitalism, in terms of profit-making of corporations, knowledge production and environmental degradation, in not being able to resolve antibiotic resistance?

What can be strategies of local communities to tackle the problem and to promote environmental justice in terms of alliances with ecologists, doctors, epidemiologists and other activists?

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Sara.Till

1) "It is important to note that these changes that incorporated gender-based violence into the human rights realm also brought the law to bear as a primary instrument of change and struggle. Calling this ‘governance feminism’, Janet Halley argues that this was the work of a certain group of feminists who came together in the 1990s, taking criminal law as a primary instrument of reform, and working in a top-down fashion to institute punishment for a global war against women."

2) "This approach inherently limits the mode of intervention. The mandate of humanitarianism – again, as defined by the new wave of ‘sans frontiere-ism’ exemplified by ` MSF – is not to reform or improve the kind of life one lives, only to preserve life itself. And yet gender-based violence is about the kind of life one lives. Under the rubric of human rights, freedom from gender-based violence is part of a parcel of rights that define what it means to be human in ways that include the right to be free from violence, the right to equality and the right to dignity"

3) "In MSF’s General Assembly debate, Rony Brauman, the former president of MSF, suggested that rather than descending into politics, humanitarians should make a distinction between describing what one witnesses, and qualifying it, which entails making a judgement. He asked one of the MSF Holland representatives, ‘How do you know the women were raped? Did you see it happening?’ Brauman proposed sticking close to what one sees, and letting others take it from there – he felt strongly that MSF should not have called for action. For him, and many others, humanitarianism is not about justice, politics or taking sides. The MSF Holland representative responded that there was a slippery slope between political neutrality and irresponsibility, and a fierce debate ensued"

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Sara.Till

Dr. Schmid's fourteen-page report includes an additional four pages of references. These references date from mid-twentieth century (1961) to mid-summer 2012 (publication of the book was 2013). The list includes studies, reports, policies, review articles, and publications, spanning from radiation absorption of Strontium to overarching reviews of nuclear energy to organizational reliability studies. These sources, if nothing else, indicate Dr. Schmid has crafted her report from multiple angles, and is not simply re-hashing Fukushima reviews. 

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Sara.Till

As mentioned earlier, this group is heavily experienced in dealing with traumatic injuries and responding to larger scenes. I imagine the hardest challenge they face is funding; they typically run on a budget made of a few hundred thousand dollars. This encompasses salaries for some personnel (although the vast majority are voluntary), classes for CPR, EMT, First aid certification, and supplies. With such a large call volume of complex cases (think of all the resources needed to treat an individual with multiple gun shots to the chest or someone who has been stabbed several times), this is quite extraordinary that they can function adequately with such little funding.

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Sara.Till

This article seems to focus more on the overarching theme of global medicine. This does include aspects of emergency response (such as discussing how various agencies respond to emergencies or how they formulate protocols) as biosecurity seeks to minimize or eradicate health emergencies. However, as the article contends, biosecurity is not a functional ideal at this time; it primarily contends that our current models of biosecurity are undermined by several factors, leaving them as simply emergency responses.

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Sara.Till

This article seems to be primarily cited by other articles concerning historical disasters. It appears, for the most part, to be very under-cited by the research community. This may be due to its nature as a primarily historical analysis of a very under represented issue. Many competing articles seem to focus on more substantial issues with direct effects on communities or directly point out failures that led to significant reduction in response capability. As argued in the article, it can be very difficult to press issues without public encouragement for the topic. 

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Sara.Till

1) Jean-Pierre Chevenement:  a key player in passing this immigration legislation, the leader has since stepped away from the political scene after running for the presidency in 2002. As the sitting minister, Mr. Chevenement has been described as a key member of the left; I'd be intrigued to see what other pieces of legislation he has worked on

2) Didier Fassin: Dr. Fassin, a reigning expert in french state anthropology, appears to bring an element of medical background to his analysis. Obviously, he seems to be a well-respected member of the anthropological community-- where and what other projects he has on-going would be interesting 

3) French healthcare: this type of legislation obviously puts a tremendous amount of strain on the general healthcare; depending on the system utilized by the French state, this could have a detrimental effect on the quality and timing of care delivered. 

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Sara.Till

While emergency response is not addressed as an overarching theme, this report focuses on the nuances of mental health within emergency response. A key, but often forgotten aspect of emergency response, the report seeks to better focus the treatment and study of mental health after an emergency. The report discusses how to better study mental illness in populations who have experienced trauma, which will further enable effective treatments. It also discusses a few interventions currently shown to help mitigate PTSD, MDD, and other disorders after a disaster event.