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"Antibiotic Resistance in Louisiana"

fdabramo

I situate my research at the crossroads of history, philosophy, sociology and anthropology of science. In the past, I have focused on epigenetics, environmental research, empirical bioethics and environmental justice, within and outside the academia, as you can read here, or here. Now I am focusing on antibiotic resistance, and I use it as a lens to interpret the contradictions of the last century derived by industrial production, environmental degradation and biomedical cultures.

What interests me is the (at that time) new epistemic discourse that since the Forties has been produced to explain morphological changes of organisms produce when they experience new environmental conditions or perturbations. Through an important experiment at the base of the so-called concept of genetic assimilation, Conrad H. Waddington showed that a thermic shock can produce changes in wings’ veins of fruit flies, changes that can eventually be inherited across generations, without the environmental trigger that caused them.

This focus on production and (genetic) storage of biological differences elicited by the environment is nowadays coupled with the knowledge produced through microbiome research that explains the phenotypic patterns that recur across generations.

In a thought-provoking twist, with microbiome research, the focus shifts from production and inheritance of biological differences to production and inheritance of biological similarities. Microbiome research shows that some phenotypic patterns are allowed by ecological communities of microorganisms composing all animals. Bacteria allow the development and functioning of our bodies within an epistemic framework that is now key to understand biology. The network of vessels composing mammals’ stomach is formed through cellular differentiation and expression of genes coordinated by bacteria. The same is true for our immune system that is coordinated by gut bacteria. Food, which is an important aspect of our lives also impacts on this microecology and mediates between our biological functions and functioning of means of production whose parts dedicated to food production have immense importance for our biology and our internal and external ecologies. Antibiotic resistance is one of the crossroads where culture, biology, history and the Anthropocene meet. Indeed, Antibiotic resistance shows that means of production of our societies have an even more widespread, deep and allegedly unexpected impact on the biology of animals and plants. The microorganism can indeed adapt to resist the selective toxicity of antibiotics. Moreover, bacteria can transfer their genetic code horizontally, by touch, so that we can acquire antibiotic resistance by eating food that functions as a vector, by hosting lice on our heads and many other contacts. Bacteria that are resistant to antibiotics that have been used as growth factors in animal husbandry and to prevent diseases in livestock and aquaculture, spread in natural ecosystems and can be found in wild species. Rivers and estuarine waters are places hosting antibiotic resistance.

Searching on PubMed (the search engine for biomedical literature) titles of articles containing the terms ‘antimicrobial’ and ‘Louisiana’ I retrieved just one twelve-years-old article. No results with terms such as 'Mississippi' or 'New Orleans'. The authors collected and analysed Oysters from both waters of Louisiana Gulf and in restaurants and food retailers in Baton Rouge. In most of the samples gathered, scientists recognised the presence of bacteria (Vibrio parahaemolyticus and Vibrio vulnificus) resistant to specific antimicrobials. Food production is indeed the first factor in terms of the quantity of antibiotics used. This use and related antibiotic resistance impact all the living beings present in a specific area, and can easily travel around the globe through many channels. As Littman & Viens have highlighted, a sustainable future is a future without antibiotics as “there may be no truly sustainable way of using antibiotics in the long-run, as microorganisms have shown to be almost infinitely adaptable since the first introduction of antibiotics” (Littman & Viens 2015). But in the meanwhile, we need to use them and antibiotic resistance is a phenomenon that can be better studied through environmental research, by analysing wild species and emissions nearby livestock, for instance.

The study that I retrieved focuses on Oysters. But what about antibiotic resistance conveyed through food that is consumed by the most?

What about exposures of communities that are living in highly polluted areas?

And what is the additive value on antibiotic resistance for individuals who experience the presence of industrial pollutants and that live in areas where cancer epidemics are registered?

In this respect, there is a strategy to cope with the issue of antibiotic resistance promoted by the Center for Disease Control and Prevention. The document doesn’t mention any action to monitor and regulate the production and usage of antibiotics in livestock. Nevertheless, the CDC wants to scrutinise, through genome sequencing, “Listeria, Salmonella, Campylobacter, and E. coli and uploads sequence data into PulseNet for nationwide monitoring of outbreaks and trends.” Moreover, the document reports that “In Fiscal Year 2019, Louisiana will begin simultaneously monitoring these isolates for resistance genes. When outbreaks are detected, local CDC-supported epidemiologists investigate the cases to stop spread.”

The questions that I would like to ask (to local ppl, activists, researchers, practitioners..) are:

What could be the epidemiologic characteristics (socioeconomic status, gender, residence..) of the populations more vulnerable to antibiotic resistance?

What is the additive role of antibiotic resistance for people living in highly polluted areas?

What is the impact of antibiotic resistance for people and patients living in areas where cancer incidence is high?

 

And on the long run I am interested in imagining possible strategies to not only living with the problem but also to tackle the problem itself, which means to develop strategies to answer the questions:

Why antibiotic resistance, which is known since a century, it’s a problem on the rise?

What is the role and interest of capitalism, in terms of profit-making of corporations, knowledge production and environmental degradation, in not being able to resolve antibiotic resistance?

What can be strategies of local communities to tackle the problem and to promote environmental justice in terms of alliances with ecologists, doctors, epidemiologists and other activists?

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ciera.williams

The shift in thought from prevention to response is well supported as a necessary move. This can obviously be seen by the occurrence of these accidents despite adequate regulation. Nuclear energy is a promising, but dangerous thing, and can quickly become disastrous despite efforts to maintain control. This was seen in the accident at Fukushima, following the earthquake and resulting tsunami in the region. Despite preparation for such an event and the existence of backup generators and batteries, responders were rendered useless in the efforts as they could not access the area. This is where the need for a prepared system of nuclear response is needed. Historically, such emergency response groups have been poorly resourced and short-lived, such as the Soviet Spetsatom developed after the Chernobyl disaster in 1986. This group, which focused on preserving lessons learned and developing response systems, was absorbed by a larger ministry with the goal of integrated disaster response.

Additionally, the author cites a number of factors that played a role in creating the Fukushima-Daiichi disaster, such as “environmental, social, and technical systems” that, due to their complexity and separate protocol, resulted in lack or preparedness for the disaster. Following the disaster, the response efforts were delayed by this lack of preparation, and the media called out TEPCO and the Japanese government for this. STS analysis is important in this aftermath as much as in the creation of the initial plan. By utilizing an interdisciplinary approach, the media (and the people) can be heard and used to reform existing policies, or create new ones. This establishes a continuously evolving system of response that can adapt and take into account many different view of disaster relief. 

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ciera.williams
Annotation of

The film largely plays on emotional appeals and drama. By documenting the interviews of the doctors, which often are about the other doctors, the viewers see just how hard it is to detach ones self from their work. There is a scene in which the doctors talk about how, despite all the issues they face in the medical setting, everything at the end of the day is about personal relationships. It even briefly touches on sex between the medical staff and how that contributes to the care given. Since the film is based on personal interviews, little to no scientific information is given about the disease and injuries seen; its all based on personal opinion. 

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ciera.williams

The article is largely a review/update on the state of the research being done into disaster-related mental health conditions. Thus all the support for the arguments is research based rather than example based. The author backs up their definition of disasters in three categories: natural, human-made nonintentional, and human-made intentional. These criteria affect the outcomes for the psyches of the victims, with the human-made disasters carrying more weight, particularily the intentional ones. 

PTSD has been continually supported in literature, and the author simply recites sources of research dating back to the Vietnam War. The WHO has since devleoped more detailed planning tools and treatment tools for victims of trauma. 

The authors also cite multiple levels of research into the risk factors for multiple mental health issues, regardless of and related to specific disasters.