Skip to main content

Search

"Antibiotic Resistance in Louisiana"

fdabramo

I situate my research at the crossroads of history, philosophy, sociology and anthropology of science. In the past, I have focused on epigenetics, environmental research, empirical bioethics and environmental justice, within and outside the academia, as you can read here, or here. Now I am focusing on antibiotic resistance, and I use it as a lens to interpret the contradictions of the last century derived by industrial production, environmental degradation and biomedical cultures.

What interests me is the (at that time) new epistemic discourse that since the Forties has been produced to explain morphological changes of organisms produce when they experience new environmental conditions or perturbations. Through an important experiment at the base of the so-called concept of genetic assimilation, Conrad H. Waddington showed that a thermic shock can produce changes in wings’ veins of fruit flies, changes that can eventually be inherited across generations, without the environmental trigger that caused them.

This focus on production and (genetic) storage of biological differences elicited by the environment is nowadays coupled with the knowledge produced through microbiome research that explains the phenotypic patterns that recur across generations.

In a thought-provoking twist, with microbiome research, the focus shifts from production and inheritance of biological differences to production and inheritance of biological similarities. Microbiome research shows that some phenotypic patterns are allowed by ecological communities of microorganisms composing all animals. Bacteria allow the development and functioning of our bodies within an epistemic framework that is now key to understand biology. The network of vessels composing mammals’ stomach is formed through cellular differentiation and expression of genes coordinated by bacteria. The same is true for our immune system that is coordinated by gut bacteria. Food, which is an important aspect of our lives also impacts on this microecology and mediates between our biological functions and functioning of means of production whose parts dedicated to food production have immense importance for our biology and our internal and external ecologies. Antibiotic resistance is one of the crossroads where culture, biology, history and the Anthropocene meet. Indeed, Antibiotic resistance shows that means of production of our societies have an even more widespread, deep and allegedly unexpected impact on the biology of animals and plants. The microorganism can indeed adapt to resist the selective toxicity of antibiotics. Moreover, bacteria can transfer their genetic code horizontally, by touch, so that we can acquire antibiotic resistance by eating food that functions as a vector, by hosting lice on our heads and many other contacts. Bacteria that are resistant to antibiotics that have been used as growth factors in animal husbandry and to prevent diseases in livestock and aquaculture, spread in natural ecosystems and can be found in wild species. Rivers and estuarine waters are places hosting antibiotic resistance.

Searching on PubMed (the search engine for biomedical literature) titles of articles containing the terms ‘antimicrobial’ and ‘Louisiana’ I retrieved just one twelve-years-old article. No results with terms such as 'Mississippi' or 'New Orleans'. The authors collected and analysed Oysters from both waters of Louisiana Gulf and in restaurants and food retailers in Baton Rouge. In most of the samples gathered, scientists recognised the presence of bacteria (Vibrio parahaemolyticus and Vibrio vulnificus) resistant to specific antimicrobials. Food production is indeed the first factor in terms of the quantity of antibiotics used. This use and related antibiotic resistance impact all the living beings present in a specific area, and can easily travel around the globe through many channels. As Littman & Viens have highlighted, a sustainable future is a future without antibiotics as “there may be no truly sustainable way of using antibiotics in the long-run, as microorganisms have shown to be almost infinitely adaptable since the first introduction of antibiotics” (Littman & Viens 2015). But in the meanwhile, we need to use them and antibiotic resistance is a phenomenon that can be better studied through environmental research, by analysing wild species and emissions nearby livestock, for instance.

The study that I retrieved focuses on Oysters. But what about antibiotic resistance conveyed through food that is consumed by the most?

What about exposures of communities that are living in highly polluted areas?

And what is the additive value on antibiotic resistance for individuals who experience the presence of industrial pollutants and that live in areas where cancer epidemics are registered?

In this respect, there is a strategy to cope with the issue of antibiotic resistance promoted by the Center for Disease Control and Prevention. The document doesn’t mention any action to monitor and regulate the production and usage of antibiotics in livestock. Nevertheless, the CDC wants to scrutinise, through genome sequencing, “Listeria, Salmonella, Campylobacter, and E. coli and uploads sequence data into PulseNet for nationwide monitoring of outbreaks and trends.” Moreover, the document reports that “In Fiscal Year 2019, Louisiana will begin simultaneously monitoring these isolates for resistance genes. When outbreaks are detected, local CDC-supported epidemiologists investigate the cases to stop spread.”

The questions that I would like to ask (to local ppl, activists, researchers, practitioners..) are:

What could be the epidemiologic characteristics (socioeconomic status, gender, residence..) of the populations more vulnerable to antibiotic resistance?

What is the additive role of antibiotic resistance for people living in highly polluted areas?

What is the impact of antibiotic resistance for people and patients living in areas where cancer incidence is high?

 

And on the long run I am interested in imagining possible strategies to not only living with the problem but also to tackle the problem itself, which means to develop strategies to answer the questions:

Why antibiotic resistance, which is known since a century, it’s a problem on the rise?

What is the role and interest of capitalism, in terms of profit-making of corporations, knowledge production and environmental degradation, in not being able to resolve antibiotic resistance?

What can be strategies of local communities to tackle the problem and to promote environmental justice in terms of alliances with ecologists, doctors, epidemiologists and other activists?

pece_annotation_1473568697

Sara_Nesheiwat

"The distribution and outcome of chronic infectious diseases, such as HIV/AIDS, are so tightly linked to social arrangements that it is difficult for clinicians treating these diseases to ignore social factors. Although AIDS is often considered a “social disease,” clinicians may have radically different understandings of what makes AIDS “social.”  

"The impact of structural violence is even more obvious in the world's poorest countries and has profound implications for those seeking to provide clinical services there.  "

"

"We can begin to address this by “resocializing” our understanding of disease distribution and outcome. Even new diseases such as AIDS have quickly become diseases of the poor, and the development of effective therapies may have a perverse effect if we are unable to use them where they are needed most.  "

pece_annotation_1480139860

Sara_Nesheiwat

The argument is supported through an analysis of current subjects of humanitarian aid and how it effects them differently and now the principle of neutrality is not apparent and discrimination is seen based off type of suffering. The argument is also supported through numerous essays from Medecins Sans Frontieres, which provide background information as well as statistical data. Also the expert analysis of the author is used to support the article based on her interpretation and experiences of gender based violence being a humanitarian problem. There is also an ample amount of facts and statistics to support the argument. 

pece_annotation_1473580107

Sara_Nesheiwat
Annotation of

American Red Cross is an organization that learns and advances as new technologies relating to medicine and disease come out, but also an organization that learns from experience. As stated earlier, the organization began with assisting with war related needs and grew from that. Due to what they learned about medical needs of the Army, they were able to flourish and grow rapidly during America's actively military war time. Attending disaster areas such as, for one example, hurricanes such as Katrina, gave volunteers an experience working with that type of disaster. Next time when an area is afflicted with a similar disaster, the organization and its members are now better equipped to handle it. 

pece_annotation_1480787676

Sara_Nesheiwat

This article focuses on the effect of violence on the heath service delivery in complex security environments on individuals, discrimination, property and more. The challenges associated with researching this are also discussed in this paper. The paper notes that there is a deficit in the ability to be able to analyze the correlation of violence and the health service delivery due to data collection. There is an overall lack of research that is health specific, publicly available and isn't gender based. This gap in research, overall limits analysis of the correlation. 

pece_annotation_1474160679

Sara_Nesheiwat

Past policies and global events are used to produce the arguments in this paper. The infrastructure set forth by the WHO and CDC in terms of biosecurity and protocols are cited repeatedly. The response to major historical outbreaks are the main details that are used in the paper in order to communicate the main points. Smallpox, flu and AIDS outbreaks are all noted as events we can learn from today in terms of threat response. 

pece_annotation_1474824166

Sara_Nesheiwat
Annotation of

Researchers use this system extensively in order to find correlations between 9/11 and different repercussions as well as to collect and gather data about those who were exposed during 9/11. A unique aspect of this registry is that it contains more participants than any other registry of its kind, making it a great tool for researchers. The public also utilizes this information to study their own forms of various research as well as to gain knowledge on possible afflictions related to the event. The registry also follows up with participants with interviews and matches with other health registries. The website also offers resources to researchers to learn more about the research at hand and where to find other published reports about 9/11.

pece_annotation_1476043945

Sara_Nesheiwat

By the public, it is regarded as a prestigious academic program that enables and creates an environment in which students can become leaders in their respective DRL careers. DRLA is also mentioned in the news alongside headlines including the USAID office of Foreign Disaster Assistance as well as Rwanda assistance and in high regards with the FEMA Chief of staff. It is clear that this program is intermingled with many governmental agencies and is regarded highly by them, as well as the public for its humanitarian efforts and abilities to produce excellent leaders in the DRL fields. It is very clear that this program is highly regarded academically, professionally and socially by the public as well. 

pece_annotation_1477243756

Sara_Nesheiwat

This is seen as a good start to a major problem that needs far more assistance and advancement. People cite that meeting eligibility requirements are very hard and there are people that make more money than allowed to qualify, but still cannot afford mental health treatment. This policy is appreciated in a certain capacity, yet it is very apparent that people want more and think more help is needed. Of course, you will always have an opposing side when it comes to politics and there are people who think this is the perfect amount of assistance and nothing else is needed.