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"Antibiotic Resistance in Louisiana"

fdabramo

I situate my research at the crossroads of history, philosophy, sociology and anthropology of science. In the past, I have focused on epigenetics, environmental research, empirical bioethics and environmental justice, within and outside the academia, as you can read here, or here. Now I am focusing on antibiotic resistance, and I use it as a lens to interpret the contradictions of the last century derived by industrial production, environmental degradation and biomedical cultures.

What interests me is the (at that time) new epistemic discourse that since the Forties has been produced to explain morphological changes of organisms produce when they experience new environmental conditions or perturbations. Through an important experiment at the base of the so-called concept of genetic assimilation, Conrad H. Waddington showed that a thermic shock can produce changes in wings’ veins of fruit flies, changes that can eventually be inherited across generations, without the environmental trigger that caused them.

This focus on production and (genetic) storage of biological differences elicited by the environment is nowadays coupled with the knowledge produced through microbiome research that explains the phenotypic patterns that recur across generations.

In a thought-provoking twist, with microbiome research, the focus shifts from production and inheritance of biological differences to production and inheritance of biological similarities. Microbiome research shows that some phenotypic patterns are allowed by ecological communities of microorganisms composing all animals. Bacteria allow the development and functioning of our bodies within an epistemic framework that is now key to understand biology. The network of vessels composing mammals’ stomach is formed through cellular differentiation and expression of genes coordinated by bacteria. The same is true for our immune system that is coordinated by gut bacteria. Food, which is an important aspect of our lives also impacts on this microecology and mediates between our biological functions and functioning of means of production whose parts dedicated to food production have immense importance for our biology and our internal and external ecologies. Antibiotic resistance is one of the crossroads where culture, biology, history and the Anthropocene meet. Indeed, Antibiotic resistance shows that means of production of our societies have an even more widespread, deep and allegedly unexpected impact on the biology of animals and plants. The microorganism can indeed adapt to resist the selective toxicity of antibiotics. Moreover, bacteria can transfer their genetic code horizontally, by touch, so that we can acquire antibiotic resistance by eating food that functions as a vector, by hosting lice on our heads and many other contacts. Bacteria that are resistant to antibiotics that have been used as growth factors in animal husbandry and to prevent diseases in livestock and aquaculture, spread in natural ecosystems and can be found in wild species. Rivers and estuarine waters are places hosting antibiotic resistance.

Searching on PubMed (the search engine for biomedical literature) titles of articles containing the terms ‘antimicrobial’ and ‘Louisiana’ I retrieved just one twelve-years-old article. No results with terms such as 'Mississippi' or 'New Orleans'. The authors collected and analysed Oysters from both waters of Louisiana Gulf and in restaurants and food retailers in Baton Rouge. In most of the samples gathered, scientists recognised the presence of bacteria (Vibrio parahaemolyticus and Vibrio vulnificus) resistant to specific antimicrobials. Food production is indeed the first factor in terms of the quantity of antibiotics used. This use and related antibiotic resistance impact all the living beings present in a specific area, and can easily travel around the globe through many channels. As Littman & Viens have highlighted, a sustainable future is a future without antibiotics as “there may be no truly sustainable way of using antibiotics in the long-run, as microorganisms have shown to be almost infinitely adaptable since the first introduction of antibiotics” (Littman & Viens 2015). But in the meanwhile, we need to use them and antibiotic resistance is a phenomenon that can be better studied through environmental research, by analysing wild species and emissions nearby livestock, for instance.

The study that I retrieved focuses on Oysters. But what about antibiotic resistance conveyed through food that is consumed by the most?

What about exposures of communities that are living in highly polluted areas?

And what is the additive value on antibiotic resistance for individuals who experience the presence of industrial pollutants and that live in areas where cancer epidemics are registered?

In this respect, there is a strategy to cope with the issue of antibiotic resistance promoted by the Center for Disease Control and Prevention. The document doesn’t mention any action to monitor and regulate the production and usage of antibiotics in livestock. Nevertheless, the CDC wants to scrutinise, through genome sequencing, “Listeria, Salmonella, Campylobacter, and E. coli and uploads sequence data into PulseNet for nationwide monitoring of outbreaks and trends.” Moreover, the document reports that “In Fiscal Year 2019, Louisiana will begin simultaneously monitoring these isolates for resistance genes. When outbreaks are detected, local CDC-supported epidemiologists investigate the cases to stop spread.”

The questions that I would like to ask (to local ppl, activists, researchers, practitioners..) are:

What could be the epidemiologic characteristics (socioeconomic status, gender, residence..) of the populations more vulnerable to antibiotic resistance?

What is the additive role of antibiotic resistance for people living in highly polluted areas?

What is the impact of antibiotic resistance for people and patients living in areas where cancer incidence is high?

 

And on the long run I am interested in imagining possible strategies to not only living with the problem but also to tackle the problem itself, which means to develop strategies to answer the questions:

Why antibiotic resistance, which is known since a century, it’s a problem on the rise?

What is the role and interest of capitalism, in terms of profit-making of corporations, knowledge production and environmental degradation, in not being able to resolve antibiotic resistance?

What can be strategies of local communities to tackle the problem and to promote environmental justice in terms of alliances with ecologists, doctors, epidemiologists and other activists?

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Sara_Nesheiwat

Emergency response was completely lacking in man power and containment efforts. There wasn't much structure to the efforts taken by emergency response in terms of containment and education of the public. There were far too many of those in need and way too few emergency response teams. Hospitals closed due to lack of personnel as well as doctors getting infected themselves. People were dying left and right and being left on the side of the street. Responders weren't able to get to people in time in some cases. Locals began to take out aggressions and frustrations on emergency responders, despite them working at full capacity. The lack of man power, communication and education lead to the emergency response being sub par in this situation. 

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Sara_Nesheiwat

Emergency response isn’t directly addressed in this article. Yet, conditions and forms of violence that are discussed in the article that emergency responders have been documented with facing, clearly effect the way they work and respond to calls. Though emergency response isn’t directly addressed, this article is very relevant to emergency responders since its implications can highly effect the work of EMS and other medical care providers.

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Sara_Nesheiwat

I researched current protocols and strategies in place in terms of biosafety. I also researched current microbial threats in terms of organisms and the ways in which we have currently developed to help prevent those specific forms of bioterrorism. I also read up on past bioterrorism events and the effects it had on global protocols as well as the development of emergency response. 

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Sara_Nesheiwat
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This site runs like any run of the mill website. If there are any issues or questions about the website there is contact information provided to seek assistance with the site or ask questions regarding the information. 

By phone: 866-692-9827
By email: wtchr@health.nyc.gov
By fax: 347-396-2893
By mail: WTC Health Registry
New York City Department of Health and Mental Hygiene
42-09 28th Street, CN 6W
Queens, NY 11101-4132

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christopher.vi…

Yes and no. Communities should be able to do something about their air quality in their area but within the state's command. For example, states should have a state regulation on air quality and be able to enforce that regulation. However, individual communities should be able to do what they want to meet that state regulation on air quality. With this, communities still have the freedom to do something about their air quality while the state maintains its power

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Sara_Nesheiwat
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The way in which the research was done is what made this an interesting read and peaked my interest in this article. Primary sources of information are quoted and interviewed. The conditions and treatment of inmates were documented and revealed by residents both past and present of Rikers, who have first hand insight into what it was like being detained there. Inmate testimony, as well as facts and statistics about the deteriorating facilities, pollution and poor conditions there were also provided. This information was supplied by numerous different organizations as well as studies and articles and then complied into this article. 

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Sara_Nesheiwat

"Depression and anxiety disorders were pervasive. Many residents had regular nightmares of waking up in water. They talked about recurring “breakdowns” in which they became overcome with emotion and physically collapsed. A 2007 study showed that 20 percent of New Orleans residents were categorized as having a Katrina-related serious mental illness, and 19 percent showed signs of minimal to mild mental illness (Sastry and VanLandingham 2008; Thomas 2008).  "

"The stress-inducing factors that prevailed among New Orleans residents were multiple and layered, including physical, psychological, and social displacements around house and home, work, financial security, and family security. The loss of home and jobs and, in some cases, the cost of rebuilding produced huge financial worries for residents. "

"What I experienced was coming back to the devastation of the city. No grocery stores, no cell phone service, certainly no phone service, no regular phone service. We actually had to get other cell phones. You know, it was a ghost town. I think I, probably, maybe not now, but I was in shock, you know, because I couldn’t take in the enormity of it. I wondered knowing the politics of the city, and the state, and actually the federal government, how it was ever going to be fixed.  "

“Chronic disaster syndrome” thus refers in this analysis to the cluster of trauma-and posttrauma-related phenomena that are at once individual, social, and political and that are associated with disaster as simultaneously causative and experiential of a chronic condition of distress in relation to displacement.  "

"Not surprisingly, residents and those still trying to return to New Orleans are asking the question: Where did all the federal money go? Residents still living out of their trailers wonder why they could not get Road Home or FEMA funds and continue to wait to find out if their rental housing will be rebuilt.  "

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Sara_Nesheiwat

The article is supported through the recollection of the past decade of research on this topic of mental health effects due to disasters. First, the article delves into the PTSD and MDD mental illness association with disasters and the background of theses disorders. The authors then utilize numerous epidemiological studies that have been developed and discussed on the matter over that last 190 years. Experiences of those that are dealing with mental illnesses are also utilized as supporting evidence of the effect disasters have on mental health conditions on those effected.