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"Antibiotic Resistance in Louisiana"

fdabramo

I situate my research at the crossroads of history, philosophy, sociology and anthropology of science. In the past, I have focused on epigenetics, environmental research, empirical bioethics and environmental justice, within and outside the academia, as you can read here, or here. Now I am focusing on antibiotic resistance, and I use it as a lens to interpret the contradictions of the last century derived by industrial production, environmental degradation and biomedical cultures.

What interests me is the (at that time) new epistemic discourse that since the Forties has been produced to explain morphological changes of organisms produce when they experience new environmental conditions or perturbations. Through an important experiment at the base of the so-called concept of genetic assimilation, Conrad H. Waddington showed that a thermic shock can produce changes in wings’ veins of fruit flies, changes that can eventually be inherited across generations, without the environmental trigger that caused them.

This focus on production and (genetic) storage of biological differences elicited by the environment is nowadays coupled with the knowledge produced through microbiome research that explains the phenotypic patterns that recur across generations.

In a thought-provoking twist, with microbiome research, the focus shifts from production and inheritance of biological differences to production and inheritance of biological similarities. Microbiome research shows that some phenotypic patterns are allowed by ecological communities of microorganisms composing all animals. Bacteria allow the development and functioning of our bodies within an epistemic framework that is now key to understand biology. The network of vessels composing mammals’ stomach is formed through cellular differentiation and expression of genes coordinated by bacteria. The same is true for our immune system that is coordinated by gut bacteria. Food, which is an important aspect of our lives also impacts on this microecology and mediates between our biological functions and functioning of means of production whose parts dedicated to food production have immense importance for our biology and our internal and external ecologies. Antibiotic resistance is one of the crossroads where culture, biology, history and the Anthropocene meet. Indeed, Antibiotic resistance shows that means of production of our societies have an even more widespread, deep and allegedly unexpected impact on the biology of animals and plants. The microorganism can indeed adapt to resist the selective toxicity of antibiotics. Moreover, bacteria can transfer their genetic code horizontally, by touch, so that we can acquire antibiotic resistance by eating food that functions as a vector, by hosting lice on our heads and many other contacts. Bacteria that are resistant to antibiotics that have been used as growth factors in animal husbandry and to prevent diseases in livestock and aquaculture, spread in natural ecosystems and can be found in wild species. Rivers and estuarine waters are places hosting antibiotic resistance.

Searching on PubMed (the search engine for biomedical literature) titles of articles containing the terms ‘antimicrobial’ and ‘Louisiana’ I retrieved just one twelve-years-old article. No results with terms such as 'Mississippi' or 'New Orleans'. The authors collected and analysed Oysters from both waters of Louisiana Gulf and in restaurants and food retailers in Baton Rouge. In most of the samples gathered, scientists recognised the presence of bacteria (Vibrio parahaemolyticus and Vibrio vulnificus) resistant to specific antimicrobials. Food production is indeed the first factor in terms of the quantity of antibiotics used. This use and related antibiotic resistance impact all the living beings present in a specific area, and can easily travel around the globe through many channels. As Littman & Viens have highlighted, a sustainable future is a future without antibiotics as “there may be no truly sustainable way of using antibiotics in the long-run, as microorganisms have shown to be almost infinitely adaptable since the first introduction of antibiotics” (Littman & Viens 2015). But in the meanwhile, we need to use them and antibiotic resistance is a phenomenon that can be better studied through environmental research, by analysing wild species and emissions nearby livestock, for instance.

The study that I retrieved focuses on Oysters. But what about antibiotic resistance conveyed through food that is consumed by the most?

What about exposures of communities that are living in highly polluted areas?

And what is the additive value on antibiotic resistance for individuals who experience the presence of industrial pollutants and that live in areas where cancer epidemics are registered?

In this respect, there is a strategy to cope with the issue of antibiotic resistance promoted by the Center for Disease Control and Prevention. The document doesn’t mention any action to monitor and regulate the production and usage of antibiotics in livestock. Nevertheless, the CDC wants to scrutinise, through genome sequencing, “Listeria, Salmonella, Campylobacter, and E. coli and uploads sequence data into PulseNet for nationwide monitoring of outbreaks and trends.” Moreover, the document reports that “In Fiscal Year 2019, Louisiana will begin simultaneously monitoring these isolates for resistance genes. When outbreaks are detected, local CDC-supported epidemiologists investigate the cases to stop spread.”

The questions that I would like to ask (to local ppl, activists, researchers, practitioners..) are:

What could be the epidemiologic characteristics (socioeconomic status, gender, residence..) of the populations more vulnerable to antibiotic resistance?

What is the additive role of antibiotic resistance for people living in highly polluted areas?

What is the impact of antibiotic resistance for people and patients living in areas where cancer incidence is high?

 

And on the long run I am interested in imagining possible strategies to not only living with the problem but also to tackle the problem itself, which means to develop strategies to answer the questions:

Why antibiotic resistance, which is known since a century, it’s a problem on the rise?

What is the role and interest of capitalism, in terms of profit-making of corporations, knowledge production and environmental degradation, in not being able to resolve antibiotic resistance?

What can be strategies of local communities to tackle the problem and to promote environmental justice in terms of alliances with ecologists, doctors, epidemiologists and other activists?

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Website with an excellent (and brief) explanation of fair use to copyrighted materials, along with a useful fair-use checklist that can be used to assist in fair-use analysis.

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Sara_Nesheiwat

The authors support their argument many ways, one being how that the rates of HIV/AIDS are so positively linked and correlated with social arrangements that it is often referred to as social disease. HIV commonly effects those that are poor and disease rates are fueled by gender inequality, racism and poverty. The article discusses how structural violence has influenced HIV progression. The article cites that structural violence influences diagnosis rates, staging and treatment. The also article references a study done in Baltimore which reports racism and poverty forms of structural violence and the effects on excess mortality among African Americans without insurance- ultimately showing  they were more likely to to be susceptible. The authors also used other historical data and research to support heir claims. Efforts through Partners in Health were made to prevent the spread and transmission of diseases in Haiti. The efforts made in Haiti and Rwanda were cited, both the positives and negatives. The article also discusses ways to incorporate more interventions to help eliminate any social influences of disease. 

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Sara_Nesheiwat

This article focuses on gender based violence and its ties with medical humanitarianism. The effects humanitarianism has on other violent acts versus ones effecting gender based acts such as rape and assault. A main point made in this article is the fact that special humanitarian attention to gender based violence in fact has a negative effect on the overall addressing of the issue in its entirety. The reason behind this being cited is the fact that it depoliticizes the issue when unprecedented attention is given to gender based violent acts. The article then notes that by paying attention to why this is failing, we can think of new ways of addressing this issues and violence, making it more equal.

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Sara_Nesheiwat
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A main concern is the fact that no disaster will ever be the same. A hurricane in one area will be very different in another area, despite the same source of destruction. This is because each areas has a different population, different needs  and different services available in each area. The most challenging part is the ability to foresee what might be good resources or equipment or forms of medical care and best to supply at each different disaster since each one is unique. 

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Sara_Nesheiwat

There are numerous authors of this paper. Foghammar is from the Stockholm International Peace Research Institute in Sweden, as well as the Karolinska Institute in Sweden. Jnag, Kyzy, Sullivan and Irwin are also from Stockholm International Peace Research Institute. Weiss is from the Fafo Research Institute in Norway and Fall is from King's College London in the UK. Foghammar is very active in foreign affairs as well as economics, global health and political science fields. Suyoun Jang researches at SIPRI in the Security and Development Program and her focus is on fragile states, security and development. Kyzy is also a  researcher at SIPRI, working on the impact evaluation of the peace program in Kyrgyzstan. Weiss has a PhD in social anthropology and her research areas include conflict, gender, political anthropology, migration and social suffering and torture. Their publications all relate to their respective fields of study within the anthropology and social science world. 

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Sara_Nesheiwat

"The demand for “public health preparedness” escalated as public health insti- tutions faced mounting concerns about, first, a possible bioterrorist attack and then, beginning in 2005, a devastating influenza pandemic. "

"There is the problem of regulation and responsibility: given the global scale of biological threats and their multiple sources, it is often unclear who has regulatory jurisdiction or responsibility for managing a 

given disease event.  "

 

"The emergency management approach thus seeks to develop techniques for managing health emergencies that can work independently of political context and of socioeconomic conditions.  "

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Sara_Nesheiwat
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This registry allows for the tracking of the health effects of the 9/11 disaster. It is open to the public, where they can see the most common disorders and afflictions that those effected by 9/11 are dealing with today. The public can access this website and read up on the rates of lung infection, heart disease, PTSD, alcohol use, as well as the effect it has had on adolescent health. This registry was not only set up for the public use though, it is also used and produced by researchers. The researchers track the longterm health effects 9/11 has had on those exposed. The data also provides experts and researchers with the means to draw conclusions and analyses. Learning about the long term effects of 9/11 will raise awareness as well as allow for the understanding of how disasters of this caliber can effect those around it, in both long term and short term ways. 

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Sara_Nesheiwat

I personally wouldn't say that emergency response was a factor discussed or addressed in this paper. Rather,there was a discussion about illegal immigration and public health aspects and the duty France and other countries had to those seeking residence or living in their respective countries. I think more so, public health aspects were discussed in this paper as well as social aspects of duty and justice rather than emergency response.