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"Antibiotic Resistance in Louisiana"

fdabramo

I situate my research at the crossroads of history, philosophy, sociology and anthropology of science. In the past, I have focused on epigenetics, environmental research, empirical bioethics and environmental justice, within and outside the academia, as you can read here, or here. Now I am focusing on antibiotic resistance, and I use it as a lens to interpret the contradictions of the last century derived by industrial production, environmental degradation and biomedical cultures.

What interests me is the (at that time) new epistemic discourse that since the Forties has been produced to explain morphological changes of organisms produce when they experience new environmental conditions or perturbations. Through an important experiment at the base of the so-called concept of genetic assimilation, Conrad H. Waddington showed that a thermic shock can produce changes in wings’ veins of fruit flies, changes that can eventually be inherited across generations, without the environmental trigger that caused them.

This focus on production and (genetic) storage of biological differences elicited by the environment is nowadays coupled with the knowledge produced through microbiome research that explains the phenotypic patterns that recur across generations.

In a thought-provoking twist, with microbiome research, the focus shifts from production and inheritance of biological differences to production and inheritance of biological similarities. Microbiome research shows that some phenotypic patterns are allowed by ecological communities of microorganisms composing all animals. Bacteria allow the development and functioning of our bodies within an epistemic framework that is now key to understand biology. The network of vessels composing mammals’ stomach is formed through cellular differentiation and expression of genes coordinated by bacteria. The same is true for our immune system that is coordinated by gut bacteria. Food, which is an important aspect of our lives also impacts on this microecology and mediates between our biological functions and functioning of means of production whose parts dedicated to food production have immense importance for our biology and our internal and external ecologies. Antibiotic resistance is one of the crossroads where culture, biology, history and the Anthropocene meet. Indeed, Antibiotic resistance shows that means of production of our societies have an even more widespread, deep and allegedly unexpected impact on the biology of animals and plants. The microorganism can indeed adapt to resist the selective toxicity of antibiotics. Moreover, bacteria can transfer their genetic code horizontally, by touch, so that we can acquire antibiotic resistance by eating food that functions as a vector, by hosting lice on our heads and many other contacts. Bacteria that are resistant to antibiotics that have been used as growth factors in animal husbandry and to prevent diseases in livestock and aquaculture, spread in natural ecosystems and can be found in wild species. Rivers and estuarine waters are places hosting antibiotic resistance.

Searching on PubMed (the search engine for biomedical literature) titles of articles containing the terms ‘antimicrobial’ and ‘Louisiana’ I retrieved just one twelve-years-old article. No results with terms such as 'Mississippi' or 'New Orleans'. The authors collected and analysed Oysters from both waters of Louisiana Gulf and in restaurants and food retailers in Baton Rouge. In most of the samples gathered, scientists recognised the presence of bacteria (Vibrio parahaemolyticus and Vibrio vulnificus) resistant to specific antimicrobials. Food production is indeed the first factor in terms of the quantity of antibiotics used. This use and related antibiotic resistance impact all the living beings present in a specific area, and can easily travel around the globe through many channels. As Littman & Viens have highlighted, a sustainable future is a future without antibiotics as “there may be no truly sustainable way of using antibiotics in the long-run, as microorganisms have shown to be almost infinitely adaptable since the first introduction of antibiotics” (Littman & Viens 2015). But in the meanwhile, we need to use them and antibiotic resistance is a phenomenon that can be better studied through environmental research, by analysing wild species and emissions nearby livestock, for instance.

The study that I retrieved focuses on Oysters. But what about antibiotic resistance conveyed through food that is consumed by the most?

What about exposures of communities that are living in highly polluted areas?

And what is the additive value on antibiotic resistance for individuals who experience the presence of industrial pollutants and that live in areas where cancer epidemics are registered?

In this respect, there is a strategy to cope with the issue of antibiotic resistance promoted by the Center for Disease Control and Prevention. The document doesn’t mention any action to monitor and regulate the production and usage of antibiotics in livestock. Nevertheless, the CDC wants to scrutinise, through genome sequencing, “Listeria, Salmonella, Campylobacter, and E. coli and uploads sequence data into PulseNet for nationwide monitoring of outbreaks and trends.” Moreover, the document reports that “In Fiscal Year 2019, Louisiana will begin simultaneously monitoring these isolates for resistance genes. When outbreaks are detected, local CDC-supported epidemiologists investigate the cases to stop spread.”

The questions that I would like to ask (to local ppl, activists, researchers, practitioners..) are:

What could be the epidemiologic characteristics (socioeconomic status, gender, residence..) of the populations more vulnerable to antibiotic resistance?

What is the additive role of antibiotic resistance for people living in highly polluted areas?

What is the impact of antibiotic resistance for people and patients living in areas where cancer incidence is high?

 

And on the long run I am interested in imagining possible strategies to not only living with the problem but also to tackle the problem itself, which means to develop strategies to answer the questions:

Why antibiotic resistance, which is known since a century, it’s a problem on the rise?

What is the role and interest of capitalism, in terms of profit-making of corporations, knowledge production and environmental degradation, in not being able to resolve antibiotic resistance?

What can be strategies of local communities to tackle the problem and to promote environmental justice in terms of alliances with ecologists, doctors, epidemiologists and other activists?

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wolmad

"In this article, we describe examples of structural violance upon people living with HIV in the US and Rawanda. In both cases, we show that it is possible to address structural violance through structural interventions."

"Susceptabiliy to infection [by HIV/AIDs] and poor outcomes is aggrivated by social factors such as poverty, gender inequality, and raceism."

"by insisting that our services be delivered equitably, even physicians who work on the distal interventions characteristic of clinical medicine have much to contribute to reducing the toll of structural violance."

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joerene.aviles

The author is Sonja D. Schmid, an associate professor at Virginia Tech in the Department of Science and Technology in Society. She specializes in STS (science, tech, and society) analysis, nuclear industries, and energy policies. In respect to emergency response, Schmid is able to use her knowledge of previous disasters, current energy technologies, and societal influences to address what we need nationally/ internationally for how we should respond to emergencies. The ability to identify the multifaceted levels of what causes disasters is important to properly responding to them- by changing technologies, training and education of communities, and changing energy policies to avoid and handle more disaster.

Publications relevant to the DSTS Network: "Evacuation from a nuclear disaster" (http://www.jstor.org/stable/214548?seq=1#page_scan_tab_contents), "A comparative institutional analysis of the Fukushima nuclear disaster: Lessons and policy implications" (http://www.sciencedirect.com/science/article/pii/S0301421512009433)

Research focusing on nuclear waste management, developments for safer nuclear energy and studies of the nuclear arms race are also relevant to DSTS Network.

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wolmad

This film is designed to have an emotional appeal. Very little scientific evidance is provided, and most of what we see are images and naratives about the effects of ebola from the public's perspective. Powerful images and stories, such as the death of a pregnant women on the side of the road, the closing of hospitals, and the turning away of patients are predominantly displayed. Much of this movie is told from the perspective of a student of the University of Wisconsin, and there was a large amount of dialouge about how he tried to get his family out of the effected zone. The only notable statistics given in the film was at the end, when the number of effected and the number of deaths were compared. 

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wolmad

1. “A series of factors – demographic changes, economic development, global travel and commerce, and conflict – ‘have heightened the risk of disease outbreaks,’ ranging from emerging infectious diseases such as HIV/AIDS and drug resistant tuberculosis to food borne pathogens and bioterrorist attacks.”

2. “Although there is a great sense of urgency to address contemporary biosecurity problems— and while impressive resources have been mobilized to do so — there is no consensus about how to conceptualize these threats, nor about what the most appropriate measures are to deal with them.”

3. “There is no such thing as being “too secure.” Living with risk, by contrast, acknowledges a more complex calculus. It requires new forms of political and ethical reasoning that take into account questions that are often only implicit in discussions of biosecurity interventions.” 

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joerene.aviles

The report implies that technical professionals have to be more careful when responding to large scale disasters; staff responding to emergencies need to have more training for the many internal challenges that would lmit care and assistance to victims. MSF discussed how they had limited man power, labs, and resources.

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wolmad

“A six­month examination by The Times found that the rescuers' ability to save themselves and others was hobbled by technical difficulties, a history of tribal feuding and management lapses that have been part of the emergency response culture in New York City and other regions for years.”

''It's a disgrace,'' he said. ''The police are talking to each other. It's a no­brainer: Get us what they're using. We send people to the moon, and you mean to tell me a firefighter can't talk to a guy two floors above him?''

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joerene.aviles

Disaster investigations look at the emergency response that followed the incident, either the timing or actions taken to save human lives. There's more about the investigations calling for improved emergency preparedness; policies and technology development to prevent disasters such as the Hague Street Explosion (1850) which involved a faulty boiler (and other factors) and the Iroquois theater fire (1903) which led to changed theater building policies.