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"Antibiotic Resistance in Louisiana"

fdabramo

I situate my research at the crossroads of history, philosophy, sociology and anthropology of science. In the past, I have focused on epigenetics, environmental research, empirical bioethics and environmental justice, within and outside the academia, as you can read here, or here. Now I am focusing on antibiotic resistance, and I use it as a lens to interpret the contradictions of the last century derived by industrial production, environmental degradation and biomedical cultures.

What interests me is the (at that time) new epistemic discourse that since the Forties has been produced to explain morphological changes of organisms produce when they experience new environmental conditions or perturbations. Through an important experiment at the base of the so-called concept of genetic assimilation, Conrad H. Waddington showed that a thermic shock can produce changes in wings’ veins of fruit flies, changes that can eventually be inherited across generations, without the environmental trigger that caused them.

This focus on production and (genetic) storage of biological differences elicited by the environment is nowadays coupled with the knowledge produced through microbiome research that explains the phenotypic patterns that recur across generations.

In a thought-provoking twist, with microbiome research, the focus shifts from production and inheritance of biological differences to production and inheritance of biological similarities. Microbiome research shows that some phenotypic patterns are allowed by ecological communities of microorganisms composing all animals. Bacteria allow the development and functioning of our bodies within an epistemic framework that is now key to understand biology. The network of vessels composing mammals’ stomach is formed through cellular differentiation and expression of genes coordinated by bacteria. The same is true for our immune system that is coordinated by gut bacteria. Food, which is an important aspect of our lives also impacts on this microecology and mediates between our biological functions and functioning of means of production whose parts dedicated to food production have immense importance for our biology and our internal and external ecologies. Antibiotic resistance is one of the crossroads where culture, biology, history and the Anthropocene meet. Indeed, Antibiotic resistance shows that means of production of our societies have an even more widespread, deep and allegedly unexpected impact on the biology of animals and plants. The microorganism can indeed adapt to resist the selective toxicity of antibiotics. Moreover, bacteria can transfer their genetic code horizontally, by touch, so that we can acquire antibiotic resistance by eating food that functions as a vector, by hosting lice on our heads and many other contacts. Bacteria that are resistant to antibiotics that have been used as growth factors in animal husbandry and to prevent diseases in livestock and aquaculture, spread in natural ecosystems and can be found in wild species. Rivers and estuarine waters are places hosting antibiotic resistance.

Searching on PubMed (the search engine for biomedical literature) titles of articles containing the terms ‘antimicrobial’ and ‘Louisiana’ I retrieved just one twelve-years-old article. No results with terms such as 'Mississippi' or 'New Orleans'. The authors collected and analysed Oysters from both waters of Louisiana Gulf and in restaurants and food retailers in Baton Rouge. In most of the samples gathered, scientists recognised the presence of bacteria (Vibrio parahaemolyticus and Vibrio vulnificus) resistant to specific antimicrobials. Food production is indeed the first factor in terms of the quantity of antibiotics used. This use and related antibiotic resistance impact all the living beings present in a specific area, and can easily travel around the globe through many channels. As Littman & Viens have highlighted, a sustainable future is a future without antibiotics as “there may be no truly sustainable way of using antibiotics in the long-run, as microorganisms have shown to be almost infinitely adaptable since the first introduction of antibiotics” (Littman & Viens 2015). But in the meanwhile, we need to use them and antibiotic resistance is a phenomenon that can be better studied through environmental research, by analysing wild species and emissions nearby livestock, for instance.

The study that I retrieved focuses on Oysters. But what about antibiotic resistance conveyed through food that is consumed by the most?

What about exposures of communities that are living in highly polluted areas?

And what is the additive value on antibiotic resistance for individuals who experience the presence of industrial pollutants and that live in areas where cancer epidemics are registered?

In this respect, there is a strategy to cope with the issue of antibiotic resistance promoted by the Center for Disease Control and Prevention. The document doesn’t mention any action to monitor and regulate the production and usage of antibiotics in livestock. Nevertheless, the CDC wants to scrutinise, through genome sequencing, “Listeria, Salmonella, Campylobacter, and E. coli and uploads sequence data into PulseNet for nationwide monitoring of outbreaks and trends.” Moreover, the document reports that “In Fiscal Year 2019, Louisiana will begin simultaneously monitoring these isolates for resistance genes. When outbreaks are detected, local CDC-supported epidemiologists investigate the cases to stop spread.”

The questions that I would like to ask (to local ppl, activists, researchers, practitioners..) are:

What could be the epidemiologic characteristics (socioeconomic status, gender, residence..) of the populations more vulnerable to antibiotic resistance?

What is the additive role of antibiotic resistance for people living in highly polluted areas?

What is the impact of antibiotic resistance for people and patients living in areas where cancer incidence is high?

 

And on the long run I am interested in imagining possible strategies to not only living with the problem but also to tackle the problem itself, which means to develop strategies to answer the questions:

Why antibiotic resistance, which is known since a century, it’s a problem on the rise?

What is the role and interest of capitalism, in terms of profit-making of corporations, knowledge production and environmental degradation, in not being able to resolve antibiotic resistance?

What can be strategies of local communities to tackle the problem and to promote environmental justice in terms of alliances with ecologists, doctors, epidemiologists and other activists?

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Alexi Martin

It brings people/organizations to face the hiding problem and improve because seeing actual statistics and the reality of what happened makes people want to act. Facts cause people to realize what had not occured, so the improper handling of hospital/evacuations will never happen again-people lost their lives. The government will realize they need to have more personalle available, as well as supplies and to control how their personalle treat others. Katrina shaped how emergency medical care works today, as every disaster is a teaching method of what to do and not to do in the future.

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Alexi Martin
  1. “Studies of traumatic event experience have shown that most people who experience an event do not develop psychopathology”

“The field of disaster mental health has strong roots in research on the mental health consequences of war, specifically stemming from the experiences of WWI, WWII and the holocaust.”

“Some studies have observed increases in the use of alcohol, drugs and cigarettes after disaster and some evidence shows that disaster victims use substances, particularly alcohol as a coping strategy.”

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Alexi Martin

The main findings of this article include the discrepancy of actual health issues and its surfacing in the government. The article explores post-Soviet Union Ukraine and discovers the backbone of its economy consists of disability healthcare for those affected by radiation. The struggle to survive without an illness on a  bare economy where government funds help those who may be damamged by radiation and ignore the rest of the population.

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Alexi Martin

The stakeholders that are described/portrayed in the film was the fate of Japan, the nuclear disasters in th past that shaked Japan, preventing the same thing from happening. The kinds of decisions they had to grapple with before the aftermath is the powerfailure, the lack of generators, and the affect the water had on the plant, and the future of the fuel rods. During the event they had to figure out how to stop the meltdown, how to restore power to the plant, how to help the engineers who had no choice but to be stuck inside, how to save Japan from nuclear fallout,etc. The aftermath was how to get the plant up and running again, the future of nuclear power in Japan, how to clean up and prevent further contamination of the land surrounding the plant. Also the health,safety and preperation of further nuclear power plant endeavors.

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Alexi Martin

The main findings in the article is that illness cannot always be black or white sometimes there is shades of gray. This is described through the way the author chose to study and publish seizure disorders in Turkey. He recorded the history of events via a narrative. This was the stories are moer beautiful and detailed. While there may be bias, the 'narratives' describe their lives, a story that can be described across a language barrier.

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Alexi Martin

The authors are Paul Farmer, Bruce Nuzeye, Sara Stulac and Salmaan Keshorjee. Farmer is a doctor and medical anthrapologist and has a human rights based approach to global healthcare. Nizeye is the chief of infrastructure for PIH in Rawanda. Stulac is an associate physician in the division of global health equity. Salmaan researches global health and social medicine at Harvard. They are all collectively professionally equipted in respect to emergency response because they all are familiar with healthcare from their fields.

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Alexi Martin

THe main findings/arguments in this article is what is humantiariasm in the face of sexual violence. How sexual violence became the perfect goal for human rights activists (medical outreach) to address. The article explains human rights movements in African countries and exemplifies what happens to those who live in war strewn countries; how sexual assualt and rape are crimes, specifically to women and the questino if men and those who are transgender are excluded and how to fix it.