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"Antibiotic Resistance in Louisiana"

fdabramo

I situate my research at the crossroads of history, philosophy, sociology and anthropology of science. In the past, I have focused on epigenetics, environmental research, empirical bioethics and environmental justice, within and outside the academia, as you can read here, or here. Now I am focusing on antibiotic resistance, and I use it as a lens to interpret the contradictions of the last century derived by industrial production, environmental degradation and biomedical cultures.

What interests me is the (at that time) new epistemic discourse that since the Forties has been produced to explain morphological changes of organisms produce when they experience new environmental conditions or perturbations. Through an important experiment at the base of the so-called concept of genetic assimilation, Conrad H. Waddington showed that a thermic shock can produce changes in wings’ veins of fruit flies, changes that can eventually be inherited across generations, without the environmental trigger that caused them.

This focus on production and (genetic) storage of biological differences elicited by the environment is nowadays coupled with the knowledge produced through microbiome research that explains the phenotypic patterns that recur across generations.

In a thought-provoking twist, with microbiome research, the focus shifts from production and inheritance of biological differences to production and inheritance of biological similarities. Microbiome research shows that some phenotypic patterns are allowed by ecological communities of microorganisms composing all animals. Bacteria allow the development and functioning of our bodies within an epistemic framework that is now key to understand biology. The network of vessels composing mammals’ stomach is formed through cellular differentiation and expression of genes coordinated by bacteria. The same is true for our immune system that is coordinated by gut bacteria. Food, which is an important aspect of our lives also impacts on this microecology and mediates between our biological functions and functioning of means of production whose parts dedicated to food production have immense importance for our biology and our internal and external ecologies. Antibiotic resistance is one of the crossroads where culture, biology, history and the Anthropocene meet. Indeed, Antibiotic resistance shows that means of production of our societies have an even more widespread, deep and allegedly unexpected impact on the biology of animals and plants. The microorganism can indeed adapt to resist the selective toxicity of antibiotics. Moreover, bacteria can transfer their genetic code horizontally, by touch, so that we can acquire antibiotic resistance by eating food that functions as a vector, by hosting lice on our heads and many other contacts. Bacteria that are resistant to antibiotics that have been used as growth factors in animal husbandry and to prevent diseases in livestock and aquaculture, spread in natural ecosystems and can be found in wild species. Rivers and estuarine waters are places hosting antibiotic resistance.

Searching on PubMed (the search engine for biomedical literature) titles of articles containing the terms ‘antimicrobial’ and ‘Louisiana’ I retrieved just one twelve-years-old article. No results with terms such as 'Mississippi' or 'New Orleans'. The authors collected and analysed Oysters from both waters of Louisiana Gulf and in restaurants and food retailers in Baton Rouge. In most of the samples gathered, scientists recognised the presence of bacteria (Vibrio parahaemolyticus and Vibrio vulnificus) resistant to specific antimicrobials. Food production is indeed the first factor in terms of the quantity of antibiotics used. This use and related antibiotic resistance impact all the living beings present in a specific area, and can easily travel around the globe through many channels. As Littman & Viens have highlighted, a sustainable future is a future without antibiotics as “there may be no truly sustainable way of using antibiotics in the long-run, as microorganisms have shown to be almost infinitely adaptable since the first introduction of antibiotics” (Littman & Viens 2015). But in the meanwhile, we need to use them and antibiotic resistance is a phenomenon that can be better studied through environmental research, by analysing wild species and emissions nearby livestock, for instance.

The study that I retrieved focuses on Oysters. But what about antibiotic resistance conveyed through food that is consumed by the most?

What about exposures of communities that are living in highly polluted areas?

And what is the additive value on antibiotic resistance for individuals who experience the presence of industrial pollutants and that live in areas where cancer epidemics are registered?

In this respect, there is a strategy to cope with the issue of antibiotic resistance promoted by the Center for Disease Control and Prevention. The document doesn’t mention any action to monitor and regulate the production and usage of antibiotics in livestock. Nevertheless, the CDC wants to scrutinise, through genome sequencing, “Listeria, Salmonella, Campylobacter, and E. coli and uploads sequence data into PulseNet for nationwide monitoring of outbreaks and trends.” Moreover, the document reports that “In Fiscal Year 2019, Louisiana will begin simultaneously monitoring these isolates for resistance genes. When outbreaks are detected, local CDC-supported epidemiologists investigate the cases to stop spread.”

The questions that I would like to ask (to local ppl, activists, researchers, practitioners..) are:

What could be the epidemiologic characteristics (socioeconomic status, gender, residence..) of the populations more vulnerable to antibiotic resistance?

What is the additive role of antibiotic resistance for people living in highly polluted areas?

What is the impact of antibiotic resistance for people and patients living in areas where cancer incidence is high?

 

And on the long run I am interested in imagining possible strategies to not only living with the problem but also to tackle the problem itself, which means to develop strategies to answer the questions:

Why antibiotic resistance, which is known since a century, it’s a problem on the rise?

What is the role and interest of capitalism, in terms of profit-making of corporations, knowledge production and environmental degradation, in not being able to resolve antibiotic resistance?

What can be strategies of local communities to tackle the problem and to promote environmental justice in terms of alliances with ecologists, doctors, epidemiologists and other activists?

Isabelle Soifer: Knowledge Economy and Settler Colonialism in the Anthropocene

isoifer

Based on what I have found thus far regarding narratives surrounding the socioeconomic state of New Orleans, there are two predominant ones I have come across: New Orleans as the “laggard,” the city of play but not work, of poor educational quality, and the other of New Orleans as a "comeback" city shaping to a knowledge-based economy following Hurricane Katrina. The former reminds me of racist stereotypes typically used to describe groups of people deemed not to fit within the white supremacist narrative of progress. The other, post-Hurricane Katrina narrative, is portrayed in the media as a phoenix rising from the ashes, one of the “most rapid and dramatic economic turnarounds in recent American history.” I felt an almost visceral reaction to the assertion of one article that “It would be wrong to say the hurricane destroyed New Orleans public schools, because there was so little worth saving even before the storm hit.” I cannot help but be reminded of “terra nullius,” the “empty land” narrative implemented by colonial powers to seize and control land, dismissing the people residing on the land as insignificant to their broader aim of economic and political dominance. In place of public schools, charter schools are perceived as an improvement—but what of the people who were displaced due to the storm and long to return, yet cannot afford to send their children to a charter school and would be forced to bus their kids across the city? Many people end up not returning to New Orleans as a result. I find it interesting to compare these pre- and post-Hurricane Katrina narratives of New Orleans with the information I find from sources such as this one: a shrinking African American population, fewer young people, less affordable housing, increased segregation, etcetera. What do these demographic changes in the city imply for the “ecosystem” deemed ideal for Innovation hubs? As this article asserts, “New Orleans is making a big name for itself among innovative industries and entrepreneurs and the city’s unique vibe plays a big role in that.” On the other hand, City Councilmember Kristen Palmer asserts that “People have been consistently pushed out…If we lose our people and our culture, we lose our city.” What implication does this “burst” in innovation in New Orleans have for both the Anthropocenics of the city as well as its culture, a culture that is stereotyped as one long “party” with intermittent “emptiness,” as opposed to the realities of the people who have resided in the city for generations, or even the people who moved away after the Hurricane and long to return but to no avail? I am curious to see how education, job training (or lack thereof), and issues of housing feed into the anthropocenics of the city. How do grassroots, social justice and environmentalist activists and organizations (such as this one) perceive the changes in the city following the Hurricane compared to innovation hub technicians and CEOs? How do the social and environmental outcomes of Hurricane Katrina fit within the history of "natural" disasters and climate change in New Orleans? I think it is important to keep articles such as this one central to our focus as we move forward with this project.

Isabelle Soifer: The Anthropocenics of the Knowledge Economy

isoifer

I’m interested in how universities, cities, and corporations develop the physical embodiment of the knowledge economy in U.S. city centers in an attempt to foster global connections, and the effect this tends to have on historically black and brown communities. What I find interesting about New Orleans is the manner in which following Hurricane Katrina (which some allege was a human-made disaster), gentrification of the city was spurred on, particularly as predominantly young, white people seeking to work in tech start-ups and corporations moved in to what is deemed yet another potential site for “Innovation.” This made room for corporations and richer residents to move in at the expense of working-class neighborhoods . As council member James Gray argued, “The area desperately needs activity and development…if the city of New Orleans is going to recover, if the Lower Ninth is going to recover- we need development. We cannot turn it away.” I came across an advertisement for an event hosted by INNO that will be held in New Orleans for a “global innovation conference” whereby innovators can “forge the connections that matter.” While I am in the preliminary stages of my research in Houston regarding the Innovation District being built in Midtown Houston, I see astonishing parallels with New Orleans and similar questions arise. Many of the employees at tech companies I have interviewed thus far speak of the notion of the “ecosystem”: the confluence of higher educational institutions, cities, corporations, and start-ups that provides the ideal environment for businesses to thrive and innovation to flourish. However, who is included in this ecosystem and who is left out? What implications (if any) does the use of such environmental terms (ecosystem) to describe innovation economies have for the anthropocene? What does innovation mean and who does it benefit? How do these innovation districts and corridors potentially exacerbate racial inequity in the city, even as they claim to be working for the benefit of all? How do infrastructural neglect and gentrification contribute to health, educational, economic, and environmental disparities, and will innovation in any way seek to address these issues, or merely perpetuate the status quo?

I'm also interested in the narratives that arise surrounding natural disasters, particularly the linear fashion in which events are described. There is a beginning, middle, and end supposedly: but what about before and after, and what about the reoccurence of these disasters? In what ways do these narratives leave out the stories of people who did not get to see the "silver lining" of a disaster? Who did not get to witness the rebuilding of the city? Many of those people moved to Houston and went through another hurricane, Hurricane Harvey. It would be interesting to trace the connections between these two cities. 

Finally, in relation to the topic of slavery, I am interested in the surge of conversations surrounding reparations, particularly in New Orleans and Houston in light of the uneven effects of hurricanes on certain populations. I am intrigued both by memorialization of slavery as well as attempts by elected officials such as Representative Sheila Jackson Lee of Houston and celebrities such as Danny Glover to conduct research (bill H.R. 40) on how to compensate for the U.S.'s history and presence of slavery and racism.