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"Antibiotic Resistance in Louisiana"

fdabramo

I situate my research at the crossroads of history, philosophy, sociology and anthropology of science. In the past, I have focused on epigenetics, environmental research, empirical bioethics and environmental justice, within and outside the academia, as you can read here, or here. Now I am focusing on antibiotic resistance, and I use it as a lens to interpret the contradictions of the last century derived by industrial production, environmental degradation and biomedical cultures.

What interests me is the (at that time) new epistemic discourse that since the Forties has been produced to explain morphological changes of organisms produce when they experience new environmental conditions or perturbations. Through an important experiment at the base of the so-called concept of genetic assimilation, Conrad H. Waddington showed that a thermic shock can produce changes in wings’ veins of fruit flies, changes that can eventually be inherited across generations, without the environmental trigger that caused them.

This focus on production and (genetic) storage of biological differences elicited by the environment is nowadays coupled with the knowledge produced through microbiome research that explains the phenotypic patterns that recur across generations.

In a thought-provoking twist, with microbiome research, the focus shifts from production and inheritance of biological differences to production and inheritance of biological similarities. Microbiome research shows that some phenotypic patterns are allowed by ecological communities of microorganisms composing all animals. Bacteria allow the development and functioning of our bodies within an epistemic framework that is now key to understand biology. The network of vessels composing mammals’ stomach is formed through cellular differentiation and expression of genes coordinated by bacteria. The same is true for our immune system that is coordinated by gut bacteria. Food, which is an important aspect of our lives also impacts on this microecology and mediates between our biological functions and functioning of means of production whose parts dedicated to food production have immense importance for our biology and our internal and external ecologies. Antibiotic resistance is one of the crossroads where culture, biology, history and the Anthropocene meet. Indeed, Antibiotic resistance shows that means of production of our societies have an even more widespread, deep and allegedly unexpected impact on the biology of animals and plants. The microorganism can indeed adapt to resist the selective toxicity of antibiotics. Moreover, bacteria can transfer their genetic code horizontally, by touch, so that we can acquire antibiotic resistance by eating food that functions as a vector, by hosting lice on our heads and many other contacts. Bacteria that are resistant to antibiotics that have been used as growth factors in animal husbandry and to prevent diseases in livestock and aquaculture, spread in natural ecosystems and can be found in wild species. Rivers and estuarine waters are places hosting antibiotic resistance.

Searching on PubMed (the search engine for biomedical literature) titles of articles containing the terms ‘antimicrobial’ and ‘Louisiana’ I retrieved just one twelve-years-old article. No results with terms such as 'Mississippi' or 'New Orleans'. The authors collected and analysed Oysters from both waters of Louisiana Gulf and in restaurants and food retailers in Baton Rouge. In most of the samples gathered, scientists recognised the presence of bacteria (Vibrio parahaemolyticus and Vibrio vulnificus) resistant to specific antimicrobials. Food production is indeed the first factor in terms of the quantity of antibiotics used. This use and related antibiotic resistance impact all the living beings present in a specific area, and can easily travel around the globe through many channels. As Littman & Viens have highlighted, a sustainable future is a future without antibiotics as “there may be no truly sustainable way of using antibiotics in the long-run, as microorganisms have shown to be almost infinitely adaptable since the first introduction of antibiotics” (Littman & Viens 2015). But in the meanwhile, we need to use them and antibiotic resistance is a phenomenon that can be better studied through environmental research, by analysing wild species and emissions nearby livestock, for instance.

The study that I retrieved focuses on Oysters. But what about antibiotic resistance conveyed through food that is consumed by the most?

What about exposures of communities that are living in highly polluted areas?

And what is the additive value on antibiotic resistance for individuals who experience the presence of industrial pollutants and that live in areas where cancer epidemics are registered?

In this respect, there is a strategy to cope with the issue of antibiotic resistance promoted by the Center for Disease Control and Prevention. The document doesn’t mention any action to monitor and regulate the production and usage of antibiotics in livestock. Nevertheless, the CDC wants to scrutinise, through genome sequencing, “Listeria, Salmonella, Campylobacter, and E. coli and uploads sequence data into PulseNet for nationwide monitoring of outbreaks and trends.” Moreover, the document reports that “In Fiscal Year 2019, Louisiana will begin simultaneously monitoring these isolates for resistance genes. When outbreaks are detected, local CDC-supported epidemiologists investigate the cases to stop spread.”

The questions that I would like to ask (to local ppl, activists, researchers, practitioners..) are:

What could be the epidemiologic characteristics (socioeconomic status, gender, residence..) of the populations more vulnerable to antibiotic resistance?

What is the additive role of antibiotic resistance for people living in highly polluted areas?

What is the impact of antibiotic resistance for people and patients living in areas where cancer incidence is high?

 

And on the long run I am interested in imagining possible strategies to not only living with the problem but also to tackle the problem itself, which means to develop strategies to answer the questions:

Why antibiotic resistance, which is known since a century, it’s a problem on the rise?

What is the role and interest of capitalism, in terms of profit-making of corporations, knowledge production and environmental degradation, in not being able to resolve antibiotic resistance?

What can be strategies of local communities to tackle the problem and to promote environmental justice in terms of alliances with ecologists, doctors, epidemiologists and other activists?

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Sara_Nesheiwat

There are two authors Andrew Lakoff and Stephen Collier. Andrew Lakoff works at USC and has roughly 40 publications. He is a professor of anthropology, sociology and communication at USC and has written many works with Stephen Collier. Collier has about 36 publications, and is a professor of international affairs at The New School. They are not directly involved in emergency response research but they do a lot of international studies related to medicine and disaster.

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Sara_Nesheiwat

Professionals can use this data to better equip themselves with the knowledge of weaknesses of the masses, in terms of what they know or don't know and what they perceive about the Influenza epidemic. Professionals can better identify where most people receive their data from and where they are most likely to get their information from. This will allow professionals to better identify vulnerable groups and better prepare those areas and groups, sculpting educational programs and informational/educational forums and outlets to them, with the hopes of increasing public health efforts.

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Sara_Nesheiwat

This author has cited this paper in his own books, as well as other papers. This article is also cited on numerous World Trade Center websites and other studies on the collapsing of the towers and disasters. This paper is also cited in a lot of online publications involving disasters in urban areas and the WTC specifically. 

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Sara_Nesheiwat

According to the publication linked below, funding for this program is provided by Bill & Melinda Gates Foundations, the Global Facility for Disaster Reduction and Recovery, and the Royal Norwegian Government. The university itself (Tulane) as well as partnering schools will sponsor certain programs or take in donations as well, to provide a trip to Africa etc. to present information or educate those in the area.

http://www2.tulane.edu/drla/upload/DRL-Publication-2015.pdf

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Sara_Nesheiwat

This article discusses the Chernobyl disaster and the management and cooperation that followed this disaster. Technologies at play, as well as government involvement, scientific knowledge and sociopolitical factors effecting this situation post disaster are also mentioned. The author also extensively reviews Chernobyl through field research based off resettled families and radiation exposed workers. The dependence of health and illness based off economics and politics is also heavily discussed. International scientific cooperation is also discussed in terms of studies done on those exposed after the disaster. 

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Sara_Nesheiwat

There is a lot of controversy behind the effects that Chernobyl had on the surrounding areas. There have been accusations of officials trying to cover it up, as well as completely denying that there were any repercussions that are current and apparent today. This report shows that there is no question about it, there is nuclear fallout as a result of the Chernobyl disaster. This will not only hold government officials and those in charge accountable, but also make the public aware of their risks and what they have been exposed to and what measures they should be taking to protect themselves and reverse and aid any effects or issues that may have occurred due to the disaster. This report exposes the real detriment that the disaster had on society and makes the public aware, allowing them to better fend for and protect themselves and also to make scientists more accountable as well as the government on ways to fix and counteract the issues that have risen due to the disaster.

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Sara_Nesheiwat

There is a separate section of the study that cites where the funding for the study came from. The study was supported by Grants-in -aid for the Cancer Control Policy from the Ministry of Health, labour and Welfare, Japan. The study also notes that the funder didn't play a role in the conduct of the study .