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"Antibiotic Resistance in Louisiana"

fdabramo

I situate my research at the crossroads of history, philosophy, sociology and anthropology of science. In the past, I have focused on epigenetics, environmental research, empirical bioethics and environmental justice, within and outside the academia, as you can read here, or here. Now I am focusing on antibiotic resistance, and I use it as a lens to interpret the contradictions of the last century derived by industrial production, environmental degradation and biomedical cultures.

What interests me is the (at that time) new epistemic discourse that since the Forties has been produced to explain morphological changes of organisms produce when they experience new environmental conditions or perturbations. Through an important experiment at the base of the so-called concept of genetic assimilation, Conrad H. Waddington showed that a thermic shock can produce changes in wings’ veins of fruit flies, changes that can eventually be inherited across generations, without the environmental trigger that caused them.

This focus on production and (genetic) storage of biological differences elicited by the environment is nowadays coupled with the knowledge produced through microbiome research that explains the phenotypic patterns that recur across generations.

In a thought-provoking twist, with microbiome research, the focus shifts from production and inheritance of biological differences to production and inheritance of biological similarities. Microbiome research shows that some phenotypic patterns are allowed by ecological communities of microorganisms composing all animals. Bacteria allow the development and functioning of our bodies within an epistemic framework that is now key to understand biology. The network of vessels composing mammals’ stomach is formed through cellular differentiation and expression of genes coordinated by bacteria. The same is true for our immune system that is coordinated by gut bacteria. Food, which is an important aspect of our lives also impacts on this microecology and mediates between our biological functions and functioning of means of production whose parts dedicated to food production have immense importance for our biology and our internal and external ecologies. Antibiotic resistance is one of the crossroads where culture, biology, history and the Anthropocene meet. Indeed, Antibiotic resistance shows that means of production of our societies have an even more widespread, deep and allegedly unexpected impact on the biology of animals and plants. The microorganism can indeed adapt to resist the selective toxicity of antibiotics. Moreover, bacteria can transfer their genetic code horizontally, by touch, so that we can acquire antibiotic resistance by eating food that functions as a vector, by hosting lice on our heads and many other contacts. Bacteria that are resistant to antibiotics that have been used as growth factors in animal husbandry and to prevent diseases in livestock and aquaculture, spread in natural ecosystems and can be found in wild species. Rivers and estuarine waters are places hosting antibiotic resistance.

Searching on PubMed (the search engine for biomedical literature) titles of articles containing the terms ‘antimicrobial’ and ‘Louisiana’ I retrieved just one twelve-years-old article. No results with terms such as 'Mississippi' or 'New Orleans'. The authors collected and analysed Oysters from both waters of Louisiana Gulf and in restaurants and food retailers in Baton Rouge. In most of the samples gathered, scientists recognised the presence of bacteria (Vibrio parahaemolyticus and Vibrio vulnificus) resistant to specific antimicrobials. Food production is indeed the first factor in terms of the quantity of antibiotics used. This use and related antibiotic resistance impact all the living beings present in a specific area, and can easily travel around the globe through many channels. As Littman & Viens have highlighted, a sustainable future is a future without antibiotics as “there may be no truly sustainable way of using antibiotics in the long-run, as microorganisms have shown to be almost infinitely adaptable since the first introduction of antibiotics” (Littman & Viens 2015). But in the meanwhile, we need to use them and antibiotic resistance is a phenomenon that can be better studied through environmental research, by analysing wild species and emissions nearby livestock, for instance.

The study that I retrieved focuses on Oysters. But what about antibiotic resistance conveyed through food that is consumed by the most?

What about exposures of communities that are living in highly polluted areas?

And what is the additive value on antibiotic resistance for individuals who experience the presence of industrial pollutants and that live in areas where cancer epidemics are registered?

In this respect, there is a strategy to cope with the issue of antibiotic resistance promoted by the Center for Disease Control and Prevention. The document doesn’t mention any action to monitor and regulate the production and usage of antibiotics in livestock. Nevertheless, the CDC wants to scrutinise, through genome sequencing, “Listeria, Salmonella, Campylobacter, and E. coli and uploads sequence data into PulseNet for nationwide monitoring of outbreaks and trends.” Moreover, the document reports that “In Fiscal Year 2019, Louisiana will begin simultaneously monitoring these isolates for resistance genes. When outbreaks are detected, local CDC-supported epidemiologists investigate the cases to stop spread.”

The questions that I would like to ask (to local ppl, activists, researchers, practitioners..) are:

What could be the epidemiologic characteristics (socioeconomic status, gender, residence..) of the populations more vulnerable to antibiotic resistance?

What is the additive role of antibiotic resistance for people living in highly polluted areas?

What is the impact of antibiotic resistance for people and patients living in areas where cancer incidence is high?

 

And on the long run I am interested in imagining possible strategies to not only living with the problem but also to tackle the problem itself, which means to develop strategies to answer the questions:

Why antibiotic resistance, which is known since a century, it’s a problem on the rise?

What is the role and interest of capitalism, in terms of profit-making of corporations, knowledge production and environmental degradation, in not being able to resolve antibiotic resistance?

What can be strategies of local communities to tackle the problem and to promote environmental justice in terms of alliances with ecologists, doctors, epidemiologists and other activists?

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ciera.williams

Aside from being discussed on the Disaster STS Network, this reading has been mentioned other places. For starters, it is a chapter of a larger book, “Nuclear Disaster at Fukushima Daiichi: Social, Political and Environmental Issues.” This book is a collection of writings by international STS scholars. Additionally, this piece has been referenced in several other writings, including the book “The Fukushima Effect: A New Geopolitical Terrain” and the article “Nuclear disaster in Taiwan: a multidimensional security challenge.” 

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ciera.williams
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There have been a number of controversial events and policies that have affected ARC policy. One of the most notable ones is the controversy in blood donation from gay men. The FDA requires that no blood can be taken from a man who has had sex with anohter man since 1977. The ARC petitioned the FDA in 2006 for the removal of the policy, though nothing has been done to address it yet. 

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ciera.williams

The artice cites WHO preparadness plans and Doctors without Borders as sources of policy on emergency response, in the context of global health. With the rise in infectious disease, there is a risk for "global threat" that is not directly targeted at a group, but rather engineered through social and economic factors. This means that emrgency preparadness is key. However, the article metions the use of Emergency repsonse as a bit of a cop-out. It is much easier to plan for the worst than prevent it from happening. The author states "... measures focused on mitigating potential emergencies are easier to implement rhan longer-term structural interventions." 

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ciera.williams
Annotation of

The film would have the most impact on the general population, like something that would be played on a news channel before prime time. The level of emotional appeal and interpersonal drama is enough to keep anyone intersted for the length of the film. The film does however paint the experience in a negative light, which could discourage professionals from pursuin mission worlk. Thats why the general population would be most receptive to the struggles. Its easy for them to say "I would do something like that if...." without having the ability to do anything. 

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ciera.williams

“In particular, the syndrome articulates the powerful way in which displacement is simultaneously recognized as a cause, symptom, and, ultimately, false cure for disasters. Chronic disaster syndrome represents the health outcome of life in an ongoing state of “disaster” or “emergency” (Agamben 1998; Fassin and Vasquez 2005) that, as in this case, is perpetuated by industries of “disaster” capitalism (Klein 2007; Klinenberg and Frank 2005). The total collapse of infrastructure and social services initiated by storm and floods produced what Naomi Klein calls the perfect conditions of “shock”—a collapse so severe as to authorize a new government arrangement in which the state contracts with private firms to provide services it previously provided”

“One of the recurring themes that we heard from those who were still displaced in trailers or temporary living situations (e.g., with relatives), but more so from those who had returned and were, in a few cases, back in their homes, was that, even if the neighborhoods were being rebuilt, people had lost so much that nothing would never be the same.”

“We were, like I said, we were close. No more. Not anymore. And some of it too is that we got away from one another and we realized how little we got in common. Or else the storm took it away. I don’t know which it is, you know. Cause I’m an analyzing person and I’ll try to figure it all out sooner or later. But it’s either we just really don’t have anything to talk about anymore, or we never did, and we just thought we did. It’s weird. …”

“This chain of events prompted residents to say things like: “We all asked, ‘Who was meaner: Katrina, Rita or FEMA? And everybody’s pointing at FEMA.’ Which is worse— Katrina, Rita or FEMA? FEMA””

“Katrina offered an opportunity for disaster capitalism to become entrenched, supported fully by the U.S. government. But the failure of an effective recovery in New Orleans has created yet another kind of “disaster”—the ongoing disaster. New Orleans offers an example of the perpetuation of a “state of emergency” that was initiated by Katrina but has been sustained by ongoing politicoeconomic machinery—a machinery that ultimately needs to “have a disaster” to justify its existence.”

“Hurricane Katrina was an “event” disaster that mobilized a “state of emergency,” which subsequently led to the authorization of a military response to an “ongoing” disaster that the failure of bureaucratic machinery helped to prolong. The “state” was erased as a functioning buffer for the poorest sectors of the socioeconomic hierarchy, and in its place a “free market” in private-sector development contracts emerged. Just as those citizens who were living paycheck to paycheck or welfare check to welfare check were evicted first by the forces of nature and then by the force of the unfettered free market authorized by the “emergency,” so too were the social programs, previously offered by the government to provide safety nets to these populations, eviscerated”

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ciera.williams

The World Health Assembly adopted resolution WHA65.4 on the global burden of mental disorders and the need for a comprehensive, coordinated response from health and social sectors at the country level. This resolution called for the creation of a plan detailing services, legislation, strategies and programmes provided for the purpose of treating mental health conditions.