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"Antibiotic Resistance in Louisiana"

fdabramo

I situate my research at the crossroads of history, philosophy, sociology and anthropology of science. In the past, I have focused on epigenetics, environmental research, empirical bioethics and environmental justice, within and outside the academia, as you can read here, or here. Now I am focusing on antibiotic resistance, and I use it as a lens to interpret the contradictions of the last century derived by industrial production, environmental degradation and biomedical cultures.

What interests me is the (at that time) new epistemic discourse that since the Forties has been produced to explain morphological changes of organisms produce when they experience new environmental conditions or perturbations. Through an important experiment at the base of the so-called concept of genetic assimilation, Conrad H. Waddington showed that a thermic shock can produce changes in wings’ veins of fruit flies, changes that can eventually be inherited across generations, without the environmental trigger that caused them.

This focus on production and (genetic) storage of biological differences elicited by the environment is nowadays coupled with the knowledge produced through microbiome research that explains the phenotypic patterns that recur across generations.

In a thought-provoking twist, with microbiome research, the focus shifts from production and inheritance of biological differences to production and inheritance of biological similarities. Microbiome research shows that some phenotypic patterns are allowed by ecological communities of microorganisms composing all animals. Bacteria allow the development and functioning of our bodies within an epistemic framework that is now key to understand biology. The network of vessels composing mammals’ stomach is formed through cellular differentiation and expression of genes coordinated by bacteria. The same is true for our immune system that is coordinated by gut bacteria. Food, which is an important aspect of our lives also impacts on this microecology and mediates between our biological functions and functioning of means of production whose parts dedicated to food production have immense importance for our biology and our internal and external ecologies. Antibiotic resistance is one of the crossroads where culture, biology, history and the Anthropocene meet. Indeed, Antibiotic resistance shows that means of production of our societies have an even more widespread, deep and allegedly unexpected impact on the biology of animals and plants. The microorganism can indeed adapt to resist the selective toxicity of antibiotics. Moreover, bacteria can transfer their genetic code horizontally, by touch, so that we can acquire antibiotic resistance by eating food that functions as a vector, by hosting lice on our heads and many other contacts. Bacteria that are resistant to antibiotics that have been used as growth factors in animal husbandry and to prevent diseases in livestock and aquaculture, spread in natural ecosystems and can be found in wild species. Rivers and estuarine waters are places hosting antibiotic resistance.

Searching on PubMed (the search engine for biomedical literature) titles of articles containing the terms ‘antimicrobial’ and ‘Louisiana’ I retrieved just one twelve-years-old article. No results with terms such as 'Mississippi' or 'New Orleans'. The authors collected and analysed Oysters from both waters of Louisiana Gulf and in restaurants and food retailers in Baton Rouge. In most of the samples gathered, scientists recognised the presence of bacteria (Vibrio parahaemolyticus and Vibrio vulnificus) resistant to specific antimicrobials. Food production is indeed the first factor in terms of the quantity of antibiotics used. This use and related antibiotic resistance impact all the living beings present in a specific area, and can easily travel around the globe through many channels. As Littman & Viens have highlighted, a sustainable future is a future without antibiotics as “there may be no truly sustainable way of using antibiotics in the long-run, as microorganisms have shown to be almost infinitely adaptable since the first introduction of antibiotics” (Littman & Viens 2015). But in the meanwhile, we need to use them and antibiotic resistance is a phenomenon that can be better studied through environmental research, by analysing wild species and emissions nearby livestock, for instance.

The study that I retrieved focuses on Oysters. But what about antibiotic resistance conveyed through food that is consumed by the most?

What about exposures of communities that are living in highly polluted areas?

And what is the additive value on antibiotic resistance for individuals who experience the presence of industrial pollutants and that live in areas where cancer epidemics are registered?

In this respect, there is a strategy to cope with the issue of antibiotic resistance promoted by the Center for Disease Control and Prevention. The document doesn’t mention any action to monitor and regulate the production and usage of antibiotics in livestock. Nevertheless, the CDC wants to scrutinise, through genome sequencing, “Listeria, Salmonella, Campylobacter, and E. coli and uploads sequence data into PulseNet for nationwide monitoring of outbreaks and trends.” Moreover, the document reports that “In Fiscal Year 2019, Louisiana will begin simultaneously monitoring these isolates for resistance genes. When outbreaks are detected, local CDC-supported epidemiologists investigate the cases to stop spread.”

The questions that I would like to ask (to local ppl, activists, researchers, practitioners..) are:

What could be the epidemiologic characteristics (socioeconomic status, gender, residence..) of the populations more vulnerable to antibiotic resistance?

What is the additive role of antibiotic resistance for people living in highly polluted areas?

What is the impact of antibiotic resistance for people and patients living in areas where cancer incidence is high?

 

And on the long run I am interested in imagining possible strategies to not only living with the problem but also to tackle the problem itself, which means to develop strategies to answer the questions:

Why antibiotic resistance, which is known since a century, it’s a problem on the rise?

What is the role and interest of capitalism, in terms of profit-making of corporations, knowledge production and environmental degradation, in not being able to resolve antibiotic resistance?

What can be strategies of local communities to tackle the problem and to promote environmental justice in terms of alliances with ecologists, doctors, epidemiologists and other activists?

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tamar.rogoszinski

The object of this study is to observe whether or not there was an overdiagnosis of thyroid cancer after the Fukushima nuclear disaster in 2011. They did this by comparing the observed prevalance of thyroid cancer in the Thyroid Screening Programme with the estimated historical controls on the assumption that there was neither nuclear accident nor screening intervention. 

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tamar.rogoszinski

Delivering AIDS Care Equitably in the United States: AIDS became a disease that disproportionately affected the poor in America. A study done in Baltimore reported how racism and poverty were the cause of excess deaths among African Americans. Efforts were made by physicians to improve community-based care and to get physicians in impoverished areas providing high standard of care. By addressing monetary barriers between poor African Americans and healthcare, dramatic improvements were made and lives were saved. Further studies were done in rural Haiti and Rwanda, which implemented the "PIH model". This model was designed to prevent excess mortality due to AIDS by preventing poverty and social inequalities. It also focused on preventing transmission of the disease. Each of these studies proved to be successful and supported the concept that biosocial circumstances are just as vital to patient care as is the molecular basis of a disease. 

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tamar.rogoszinski

The main argument in this film is that there is a clear lack of infrastructure in Liberia. Points of intervention that would build more infrastructure or provide better public health education would be good points of intervention. 

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tamar.rogoszinski

According to Google Scholar, this article has only been cited once. The publication's name is "Documenting Attacks on Health Workers and Facilities in Armed Conflicts." This publication discusses attacks on health facilities and workers in Afghanistan, Central African Republic, South Sudan, Syrian Arab Republic and Yemen.

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tamar.rogoszinski

OSHA was created with the Occupational Safe and Health Act of 1970 and is part of the US Department of Labor. The legislation was passed because the system of mass production used in the US encouraged the use of machinery, but there was nothing to protect workplace safety. For most employers, it was cheaper to replace a dead or injured worker than it was to introduce safety measures. Many states also enacted workers' compensation laws as labor unions began to become more popular. These laws discouraged employers from permitting unsafe workplaces. A chemical revolution also introduced chemical compounds into the workplace, which jeopardized the safety of workers. These events led to the creation of the legislation and OSHA, highlighting their primary mission.

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KRISTIJONAS.KERTENIS
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Nearly half of Newark's school's are contaminated with dangerous levels of lead. Or so they were two years ago when this article was published. This relates to infrastructure because we are poisoning poor, primarily black and hispanic communities, whom already have low resilience. Because they live in empowerished neighborhouds, their children go to lower income schools, and when they drink the water provided there, they put themselves at risk of cancer, infertillity, and other results of lead poisoning. If Newark's infrastructure was more balanced between white and black communities, there would not be impoverished areas that have poisonous drinking water at schools, as the water standard in the schools would have been raised to that of higher income communities.